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Humani serumski albumin - najvažniji transportni protein u krvi
Farmaceutski glasnik, 73 (2017), 11; 793-808. urn:nbn:hr:163:432994
Rimac, Hrvoje; Bojić, Mirza

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Rimac, H. & Bojić, M. (2017). Humani serumski albumin - najvažniji transportni protein u krvi. Farmaceutski glasnik, 73. (11), 793-808. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:432994

Rimac, Hrvoje and Mirza Bojić. "Humani serumski albumin - najvažniji transportni protein u krvi." Farmaceutski glasnik, vol. 73, no. 11, 2017, pp. 793-808. https://urn.nsk.hr/urn:nbn:hr:163:432994

Rimac, Hrvoje and Mirza Bojić. "Humani serumski albumin - najvažniji transportni protein u krvi." Farmaceutski glasnik 73, no. 11 (2017): 793-808. https://urn.nsk.hr/urn:nbn:hr:163:432994

Rimac, H. and Bojić, M. (2017) 'Humani serumski albumin - najvažniji transportni protein u krvi', Farmaceutski glasnik, 73(11), pp. 793-808. Available at: https://urn.nsk.hr/urn:nbn:hr:163:432994 (Accessed 26 November 2024)

Rimac H, Bojić M. Humani serumski albumin - najvažniji transportni protein u krvi. Farmaceutski glasnik [Internet]. 2017 [cited 2024 November 26];73(11):793-808. Available at: https://urn.nsk.hr/urn:nbn:hr:163:432994

H. Rimac and M. Bojić, "Humani serumski albumin - najvažniji transportni protein u krvi", Farmaceutski glasnik, vol. 73, no. 11, pp. 793-808, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:432994. [Accessed: 26 November 2024]

Metadata
Title (croatian)Humani serumski albumin - najvažniji transportni protein u krvi
AuthorHrvoje Rimac
AuthorMirza Bojić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Human serum albumin (HSA) is the most abundant protein in human serum. It bas numerous functions, one of which is transport of small hydrophobic molecules, such as metabolites, hormones, and nutrients, as well as drugs and toxins. This promiscuous, nonspecific affinity can !cad to competition and displacement of different ligand in binding to HSA and cause increase in toxicity of displaced ligands. In this paper, the most important HSA binding sites are described and the risk of displacement interactions between different ligands is discused. W hile such interactions are more common between physiological (e.g. fatty acids, bilirubin, heme etc) and patophysiological ligands (e.g. indoxyl sulfate, indol-3-acetate, hypuric acid, and CMPF) and drugs, displacement interactions between drugs are also known. In certain cases these interactions can direct!y influence drug's free, active concentration in blood.
Keywords (croatian)
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleFarmaceutski glasnik
Numberingvol. 73, no. 11, pp. 793-808
p-ISSN0014-8202
URN:NBNurn:nbn:hr:163:432994
Publication2017
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-06-19 10:39:31