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Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu
Farmaceutski glasnik, 71 (2015), 10; 529-535. urn:nbn:hr:163:132347
Bojić, Mirza

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Bojić, M. (2015). Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu. Farmaceutski glasnik, 71. (10), 529-535. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:132347

Bojić, Mirza. "Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu." Farmaceutski glasnik, vol. 71, no. 10, 2015, pp. 529-535. https://urn.nsk.hr/urn:nbn:hr:163:132347

Bojić, Mirza. "Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu." Farmaceutski glasnik 71, no. 10 (2015): 529-535. https://urn.nsk.hr/urn:nbn:hr:163:132347

Bojić, M. (2015) 'Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu', Farmaceutski glasnik, 71(10), pp. 529-535. Available at: https://urn.nsk.hr/urn:nbn:hr:163:132347 (Accessed 26 November 2024)

Bojić M. Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu. Farmaceutski glasnik [Internet]. 2015 [cited 2024 November 26];71(10):529-535. Available at: https://urn.nsk.hr/urn:nbn:hr:163:132347

M. Bojić, "Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu", Farmaceutski glasnik, vol. 71, no. 10, pp. 529-535, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:132347. [Accessed: 26 November 2024]

Metadata
Title (croatian)Posljednja karika u biotransformaciji acetilsalicilne kiseline: Nove spoznaje o metabolizmu
AuthorMirza Bojić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
The history of salicylates began four millennia ago. Salicylates were used for centuries in the form of a herba drug - willow bark. Isolation of salicin started in 1829, followed by the first synthesis in 1857. lt took four decades to find the acetylated form of salicylic acid that could be obtained as a pure substance. Aspirin was born in 1897. Salicylates were unique drugs in many ways. The first clinical trial was conducted in 1763 and confirmed the antipyretic activity of willow bark. In 1899, clinical trials confirmed the beneficial effects of aspirin, granting aspirin the status of a panacea (universal remedy). Owing to its analgesic, antipyretic, anti-inflammatory and antithrombotic properties, aspirin is one of the most widely used drugs today. Every fifth adult takes aspirin on a daily basis, and every second person aged 65 and above. The metabolism of aspirin is revisited in this paper, highlighting the latest achievements in researching its metabolic fare. Hydrolysis, glucuronidation and glycine conjugation, as major metabolic reactions, are covered accompanied with the minor metabolic pathway of aromatic hydroxylation. Addition of human cytochromes P450 completes the biotransformation schemc of (acetyl)salicylic acid.
Keywords (croatian)
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleFarmaceutski glasnik
Numberingvol. 71, no. 10, pp. 529-535
p-ISSN0014-8202
URN:NBNurn:nbn:hr:163:132347
Publication2015
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-10-01 15:43:18