| Abstract (english) | Stress proteins (also known as heat shock proteins) regulate fundamental cellular processes,
such as protein folding, sorting, degradation, translocation and assembly, playing
an important role in cell signaling, cytoskeletal organisation, apoptosis, antigen
presentation, cell migration, proliferation and adhesion. Heat shock proteins are divided
into families based on molecular mass: small, hsp40-60, hsp70, hsp90, hspllO.
The best characterized family is hsp70 familiy. Hsp70 is induced by a number of stress
stimuli, and its expression is regulated at transcriptional level by heat shock factor.
There are many potential medical application of stress response, from cardiovascular
diseases and graft preservation to immunotherapy of cancer. |
