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master's thesis
Razvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. urn:nbn:hr:163:199502
Ćurt, Emily
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Ćurt, E. (2019). Razvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:199502

Ćurt, Emily. "Razvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:199502

Ćurt, Emily. "Razvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:199502

Ćurt, E. (2019). 'Razvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 04 April 2025, https://urn.nsk.hr/urn:nbn:hr:163:199502

Ćurt E. Razvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2019 [cited 2025 April 04] Available at: https://urn.nsk.hr/urn:nbn:hr:163:199502

E. Ćurt, "Razvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:163:199502

Metadata
TitleRazvoj in situ gelirajuće suspenzije flutikazonpropionata za nazalnu primjenu
Title (english)Development of in situ gelling fluticasone propionate suspension for nasal administration
AuthorEmily Ćurt
MentorAnita Hafner (mentor)
Committee memberAnita Hafner (predsjednik povjerenstva)
Committee memberMario Jug (član povjerenstva)
Committee memberDubravka Vitali Čepo (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2019-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Nazalna primjena ističe se kao jednostavan i učinkovit način primjene lijekova u liječenju oboljenja nosne sluznice, a predstavlja i zanimljiv alternativni put sistemske dostave lijeka. U skladu s time, razvijaju se inovativni terapijski sustavi koji poboljšavaju farmakokinetička svojstva nazalno primijenjenog lijeka. Tako je primjenom in situ gelirajućih sustava moguće produljiti zadržavanje lijeka na mjestu primjene i povećati mu bioraspoloživost. Radi se o sustavima koji se primjenjuju u... More tekućem obliku, a u dodiru sa nosnom sluznicom geliraju pod utjecajem fizioloških čimbenika. Cilj ovoga rada bio je pripremiti in situ gelirajuće suspenzije flutikazonpropionata različitog polimernog sastava, različitog masenog omjera flutikazonpropionata i suspendirajuće tvari i prilagođene osmolalnosti s obzirom na nazalni put primjene, te ispitati utjecaj sastava in situ gelirajuće suspenzije na viskoznost u mirovanju, kut raspršenja i raspodjelu veličine raspršenih kapljica. Pripremljene su in situ gelirajuće suspenzije flutikazonpropionata (0,1%, m/m) uz neionski surfaktant polisorbat 80 (0,01% ili 0,05%, m/m) i s različitim koncentracijama polimera: pektina (0,5-0,7%, m/m), gelan gume (0,1-0,2%, m/m) i natrijevog hijaluronata (0,05%, m/m), te uz dodatak manitola (4%, m/m) kao sredstva za izotonizaciju. Nakon miješanja sa simuliranim nosnim fluidom i mjerenja osmolalosti pripremljenih suspenzija, zaključeno je da su svi ispitani uzorci kompatibilni sa nosnom sluznicom s obzirom na njihovu toničnost. In situ gelirajuće suspenzije flutikazonpropionata pripravljene iz više polimera, odnosno s većom ukupnom koncentracijom polimera, bile su karakterizirane većom viskoznošću pri mirovanju, kao i manjim kutom raspršenja. Raspodjela veličine raspršenih kapljica odgovara nazalnoj primjeni. Naime, izmjereni volumni promjeri upućuju na zaključak da će se većina primijenjene doze raspršivanjem odložiti u nosnoj šupljini s obzirom da veličina raspršenih kapljica prelazi 10 m. Rezultati ovoga rada mogu se primijeniti na daljnja istraživanja u području nazalne primjene in situ gelirajućih sustava. Less
Abstract (english)
Nasal delivery stands out as a simple and effective route of drug administration for the treatment of nasal mucosa diseases; however it also represents an interesting alternative for systemic drug delivery. Accordingly, innovative drug delivery systems are being developed that improve the pharmacokinetic properties of the nasally administered drugs. By using in situ gelling systems it is possible to prolong the drug retention at the application site and increase its bioavailability. These... More systems are applied in liquid form and gel in contact with the nasal mucosa under the influence of physiological factors. The aim of this thesis was to prepare in situ gelling fluticasone propionate suspensions of appropriate osmolality in relation to nasal route of administration, differing in polymeric composition and fluticasone propionate to suspending agent weight ratio, and to evaluate the influence of the composition of in situ gelling suspension on zero-shear viscosity as well as droplet size distribution and cone angle upon spraying. In situ gelling suspensions of fluticasone propionate (0.1%, w/w) were prepared with non-ionic surfactant polysorbate 80 (0.01% or 0.05%, w/w) and with different polymer concentrations (pectin (0.5-0.7%, w/w), gellan gum (0.1-0.2%, w/w) and sodium hyaluronate (0.05%, w/w)), with the addition of mannitol (4%, w/w) as isotonizing agent. After mixing with the simulated nasal fluid and measuring the osmolality of prepared suspensions, it was concluded that all the samples were compatible with the nasal mucosa with respect to their tonicity. The in situ gelling suspensions of fluticasone propionate prepared from multiple polymers and with a higher total polymer concentration were characterized by higher zero-shear viscosity, as well as smaller cone angle. The droplet size distribution corresponds to nasal administration since the measured volume diameters indicate that most of the applied dose by spraying will be deposited in the nasal cavity as the size of the spray droplets exceeds 10 m. The results of this thesis can be applied to further studies in the field of nasal application of in situ gelling systems. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:199502
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-04-23 09:37:32
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