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master's thesis
Utjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. urn:nbn:hr:163:121774
Odobašić, Dunja
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of general and inorganic chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Odobašić, D. (2020). Utjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:121774

Odobašić, Dunja. "Utjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:163:121774

Odobašić, Dunja. "Utjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:163:121774

Odobašić, D. (2020). 'Utjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 27 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:121774

Odobašić D. Utjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2020 [cited 2024 November 27] Available at: https://urn.nsk.hr/urn:nbn:hr:163:121774

D. Odobašić, "Utjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:163:121774

Metadata
TitleUtjecaj glikozilacije alfa1-kiselog glikoproteina na vezanje dipiridamola, imatiniba i azitromicina
Title (english)Influence of glycosylation of alpha1-acid glycoprotein on the binding of dipyridamole, imatinib and azithromycin
AuthorDunja Odobašić
MentorMario Gabričević (mentor)
Committee memberMario Gabričević (predsjednik povjerenstva)
Committee memberTin Weitner (član povjerenstva)
Committee memberSanja Dabelić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of general and inorganic chemistry)
Zagreb
Defense date and country2020-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U sklopu ovoga diplomskoga rada provedeno je ispitivanje kako promjena glikozilacijskog uzorka α1-kiselog glikoproteina utječe na konstantu vezanja dipiridamola, imatiniba i azitromicina. Tehnika korištena u ispitivanju bila je fluorescencijska spektroskopija. Rezultati ispitivanja ukazuju na to da desijalinizacija α1-kiselog glikoproteina uzrokuje promjene u konstantama vezanja izabranih lijekova i α1-kiselog glikoproteina. Desijalinizacija navedenog proteina kod imatiniba uzrokuje blago povećanje konstante vezanja za razliku od dipiridamola gdje je učinak suprotan, odnosno nakon desijalinizacije α1-kiselog glikoproteina dipiridamol se slabije veže za takav oblik te je manja i konstanta vezanja. Zbog male konstante vezanje i premalog raspona koncentracija, mjerenja provedena za azitromicin nisu relevantna.
Abstract (english)
Within the scope of this diploma thesis, the effect of the binding constant of dipyridamole, imatinib and azithromycin on the α1-acid glycoprotein due to a change in the pattern of it's glycosylation was examined by fluorescence spectroscopy. Result indicates effect of desialylation of α1-acid glycoprotein on binding constants of selected drugs. Desialylation of α1-acid glycoprotein will slightly increase the binding constant for imatinib. On the other hand, desialylation of the same protein will reduce the binding constant for dipyridamole. Due to small binding constant and narrow range of used concentrations, measurements of azithromycin binding was not succesfull.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:121774
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-04-23 13:47:00