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master's thesis
Glikirani albumin-novi biokemijski marker šećerne bolesti
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. urn:nbn:hr:163:518308
Dumanić, Petra
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medical biochemistry and haematology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Dumanić, P. (2020). Glikirani albumin-novi biokemijski marker šećerne bolesti (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:518308

Dumanić, Petra. "Glikirani albumin-novi biokemijski marker šećerne bolesti." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:163:518308

Dumanić, Petra. "Glikirani albumin-novi biokemijski marker šećerne bolesti." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:163:518308

Dumanić, P. (2020). 'Glikirani albumin-novi biokemijski marker šećerne bolesti', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:518308

Dumanić P. Glikirani albumin-novi biokemijski marker šećerne bolesti [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2020 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:518308

P. Dumanić, "Glikirani albumin-novi biokemijski marker šećerne bolesti", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:163:518308

Metadata
TitleGlikirani albumin-novi biokemijski marker šećerne bolesti
Title (english)Glycated albumin-new biomarker in diabeties mellitus
AuthorPetra Dumanić
MentorRoberta Petlevski (mentor)
Committee memberRoberta Petlevski (predsjednik povjerenstva)
Committee memberAnita Somborac Bačura (član povjerenstva)
Committee memberAna-Marija Domijan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Zagreb
Defense date and country2020-07-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract
Glikirani albumin je marker šećerne bolesti koji se smatra drugim izborom nakon glikiranog hemoglobina. Životni vijek glikiranog albumina je 2-4 tjedna pa nam tako pokazuje ranije komplikacije šećerne bolesti. Uz nove, pouzdane analitičke metode detekcije, kao što je enzimatska metoda, glikirani albumin je dobio sve učestaliju primjenu u laboratorijima. HbA1c kao „zlatni standard“ ne može dati pouzdane rezultate u slučajevima anemija, hemoglobinopatija, pacijenata na dijalizi i gestacijskog dijabetesa. Uvođenjem glikiranog albumina kao pretragu izbora za ta patološka stanja, znatno se poboljšala prevencija komplikacija šećernih bolesti u tih pacijenata. Ostali biomarkeri kao što su 1,5-anhidroglucitol, fetuin-A, razne mikroRNA, trigliceridi, lipoproteini i upalni biljezi, isto pridonose razvitku idealne kombinacije biomarkera za otkriće šećerne bolesti u najranijoj fazi. Međutim, potrebna su još daljnja istraživanja da bi se značajno proširio broj pretraga za probir šećerne bolesti.
Abstract (english)
Glycated albumin is a marker of diabetes that is considered the second choice after glycated hemoglobin. The lifespan of glycated albumin is 2-4 weeks, so it shows us the earlier complications of diabetes. With new, reliable analytical detection methods, such as the enzymatic method, glycated albumin has gained increasing use in laboratories. HbA1c as the "gold standard" cannot give reliable results in cases of anemia, hemoglobinopathy, patients at dialysis and gestational diabetes. The introduction of glycated albumin as a choice for these pathological conditions has significantly improved the prevention of complications of diabetes in these patients. Other biomarkers such as 1,5-anhydroglucitol, fetuin-A, various microRNAs, triglycerides, lipoproteins, and inflammatory markers also contribute to the development of an ideal combination of biomarkers for the detection of diabetes at the earliest stage. However, further research is needed to significantly expand the number of diabetes screening tests.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:518308
Study programmeTitle: Medical biochemistry
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra medicinske biokemije i laboratorijske medicine (magistar/magistra medicinske biokemije i laboratorijske medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-04-27 14:05:54