Due to the aging of the population and the increase in the prevalence of chronic diseases, as well as polytherapy and drug’s side effects, there is a need to rationalize therapy and in some cases to deprescribe drugs. Deprescribing represents a structured process of stopping an inappropriate drug or reducing its dose, under the supervision of health professionals, with the goal of improving treatment outcomes. Understanding the patient's attitudes about deprescription, which was the goal of this thesis, contributes to the greater success of deprescribing. Patients' attitudes were surveyed through a revised PATD questionnaire, which is the first time such a survey has been conducted in Croatia. The study included patients over the age of 40 who were taking drugs in chronic therapy for at least a month. In addition to the revised PATD questionnaire, the respondents answered questions related to the involvement of pharmacists in the process of deprescribing, and had the opportunity to write which drugs they would like to remove from their therapy and those they would like to keep in therapy. General and clinical data of the subjects were also collected. This cross-sectional observational study was conducted in public pharmacies in Zagreb from January to March 2020. The Ethics Committee of the Gradske ljekarne Zagreb approved the implementation of the research. The study included 112 subjects whose median age was 70 (range 41-90), while the median number of medications they were taking was 4 (range 1-11). Analysis of the results of the revised PATD questionnaire indicated high patient involvement in their therapy, low burden from their medications, and low concern about discontinuation of therapy, with a high belief in the appropriateness of drugs in their therapy. Statistically significant differences were observed between older and younger patients; patients younger than 65 years felt greater concern about discontinuation of therapy (p = 0.011). There was a statistically significant difference between the groups of patients who took four or less drugs and those who took five or more drugs; patients who had a higher number of drugs in therapy felt a greater burden of their own therapy (p <0.001) and showed greater involvement in their therapy (p = 0.016). In addition, as many as 94.6% of respondents agreed that they would like to stop taking one or more medications if their doctor told them it was possible, and 75% of respondents would feel comfortable if a pharmacist was involved in the deprescribing process. In conclusion, according to the obtained results, the patient's attitudes indicate the readiness of patients in the study population to deprescribe drugs with the need to overcome smaller barriers.