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professional thesis
Priprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. urn:nbn:hr:163:080847
Naletilić, Gordana
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Naletilić, G. (2020). Priprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban (Professional thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:080847

Naletilić, Gordana. "Priprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban." Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:163:080847

Naletilić, Gordana. "Priprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban." Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2020. https://urn.nsk.hr/urn:nbn:hr:163:080847

Naletilić, G. (2020). 'Priprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban', Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:080847

Naletilić G. Priprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban [Professional thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2020 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:080847

G. Naletilić, "Priprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban", Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:163:080847

Metadata
TitlePriprava i karakterizacija termoosjetljivog hidrogela s ekstraktom vrste Centella asiatica L. Urban
AuthorGordana Naletilić
MentorJelena Filipović-Grčić (mentor)
Committee memberSanda Vladimir-Knežević (predsjednik povjerenstva)
Committee memberJelena Filipović-Grčić (član povjerenstva)
Committee memberBiserka Cetina-Čižmek (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2020, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Tehnološko pitanje je bilo mogu li se pripraviti stabilni i kozmetički prihvatljivi temperaturno osjetjivi hidrogelovi na bazi poloksamera i hijaluronske kiseline s dodatkom ekstrakata biljke Centella asiatica i/ili ekstrakta crvene alge, Coralline extract. Biološko pitanje je bilo hoće li hidrogelovi i kako utjecati na hidrataciju kože. Hidrogelovi su pripravljeni jednostavnom metodom otapanja polimera i dodatka ekstrakata. Karakterizirani su s obzirom na veličinu čestica i reološka svojstva te je pokazano da se kombiniranjem 10 o/o poloksamera s 1 o/o hijaluronske kiseline mogu pripraviti stabilni hidrogelovi čija je kritična temperatura geliranja između 27 i 35 °C te mogu uklapati 5 ili 10 o/o ekstrakata bez da im se značajno promijeni svojstvo geliranja i viskoznost. Hidratacijska svojstva hidrogelova su ispitana na koži podlaktice zdravih dobrovoljaca korištenjem neinvazivne biometrijske metode pomoću MoisturMap MMlOO uređaja. Analizirane su slike površine kože na koju jesu ili nisu primijenjeni uzorci hidrogelova s obzirom na razinu sivog (Gray Index). Rezultati su pokazali da već i sam kombinirani hidrogel poloksamera i hijaluronske kiseline posjeduje hidratacijska svojstva a najbolja hidratacijska svojstva su pokazali hidrogelovi s ekstraktom crvene alge i kombinacijom ekstrakta crvene alge i ekstrakta C. asisatice u kojem je bio prisutan glicerol. Rezultati predstavljaju doprinos razvoju temperaturno osjetljivih hidrogelova za hidrataciju kože i normalno funkcioniranje epidermalne barijere.
Abstract (english)
The technological question was whether stable and cosmetically acceptable temperature-sensitive hydrogels based on poloxamer and hyaluronic acid with the addition of extracts of Centella asiatica plant and/or red algae extract, Coralline extract could be prepared. The biological question was whether and how hydrogels affect skin hydration. Hydrogels were prepared by a simple polymer dissolution method and addition of extracts. They were characterized by particle size distribution and rheological properties and it has been demonstrated that by combining 10% of poloxamer and 1 % of hyaluronic acid, stable hydrogels with a critical gelling temperature between 27 and 35 ° C can be prepared. The addition of S or 10% of the extracts didn't significantly changed their properties of gela ti on and viscosity. Hidratation hydrogel properties were tested on the forearms of healthy volunteers by noninvasive biometric methods using MoisturMap devices. Skin images were analyzed with regard to the level of the gray surface of the skin to which hydrogel samples were or were not applied. Results have shown that the combined poloxamer and hyaluronic acid hydrogel have hydration properties and the best hydration properties have been demonstrated by hydrogels with red algae extracts and a combination of red algae extracts and C. asisatice extract in which glycerol was present. The results represent a contribution to the development of temperature-sensitive hydrogels for skin hydration and norma! functioning of the epiderma! barrier.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:080847
Study programmeTitle: Dermopharmacy and cosmetology
Study programme type: university
Study level: postgraduate specialist
Academic / professional title: sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije (sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije)
Type of resourceText
File originReformatted digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-05-06 13:18:07