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master's thesis
Liposomi kao nosači djelatnih tvari biljnog porijekla
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. urn:nbn:hr:163:760033
Palac, Mirna
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Palac, M. (2019). Liposomi kao nosači djelatnih tvari biljnog porijekla (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:760033

Palac, Mirna. "Liposomi kao nosači djelatnih tvari biljnog porijekla." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:760033

Palac, Mirna. "Liposomi kao nosači djelatnih tvari biljnog porijekla." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:760033

Palac, M. (2019). 'Liposomi kao nosači djelatnih tvari biljnog porijekla', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 18 May 2024, https://urn.nsk.hr/urn:nbn:hr:163:760033

Palac M. Liposomi kao nosači djelatnih tvari biljnog porijekla [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2019 [cited 2024 May 18] Available at: https://urn.nsk.hr/urn:nbn:hr:163:760033

M. Palac, "Liposomi kao nosači djelatnih tvari biljnog porijekla", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:163:760033

Metadata
TitleLiposomi kao nosači djelatnih tvari biljnog porijekla
Title (english)Liposomes as carriers for bioactive compounds of herbal origin
AuthorMirna Palac
MentorŽeljka Vanić (mentor)
Committee memberŽeljka Vanić (predsjednik povjerenstva)
Committee memberSanda Vladimir-Knežević (član povjerenstva)
Committee memberRenata Jurišić Grubešić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2019-07-10, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Biološki aktivni spojevi poput alkaloida, terpena, polifenola i saponina mogu biti izolirani iz biljaka te se potom koristiti kao lijekovi ili kao ishodišne sirovine za razvoj novih (polu)sintetskih lijekova. Međutim, djelatne tvari biljnog porijekla uglavnom su kompleksne organske molekule, velike molekulske mase, kemijski nestabilne i slabe topljivosti što ograničava njihovu kliničku primjenu zbog loše apsorpcije te posljedično niske bioraspoloživosti. Uklapanjem u biorazgradive i biokompatibilne nanosustave moguće je poboljšati farmakokinetička i farmakodinamska svojstva biljnih lijekova i time značajno unaprijediti terapiju. Među brojnim istraživanim nanosustavima primjena liposoma je od iznimnog značaja zbog mogućnosti postizanja ciljane terapije na nivou oboljelih organa, tkiva ili unutarstaničnom nivou, potenciranja biološkog učinka, povećanju stabilnosti uklopljenog biljnog materijala, povećanja bioraspoloživosti, poboljšanog sigurnosnog profila formulacije, smanjenja neželjenih nuspojava i toksičnosti na zdrave stanice. Provedena najznačajnija ex vivo, in vivo i klinička istraživanja obuhvaćena ovim radom sistematizirano su prikazana prema kemizmu uklopljene djelatne tvari.
Abstract (english)
Biologically active phytochemicals such as alkaloids, terpenes, polyphenols and saponins can be isolated from plants and formulated as drugs or used as crude materials for development of (semi)synthetic drugs. Generally, phytochemicals are complex organic molecules, characterized by a large molecular weight, chemical instability and low water solubility, causing poor absorption, low bioaivailability and therefore limited clinical use. Incorporation of phytochemicals into biodegradable and biocompatible nanosystems can improve their pharmacokinetic and pharmacodynamic properties and thus significantly enhance the therapeutic outcome. Among the numerous investigated nanocarriers, liposomes have been demonstrated to be particularly suitable due to the proven ability to: achieve accumulation of the phytochemicals in the diseased tissues or intracellularly, potentiate biological effects and bioaivailability, enhance stability of the incorporated plant material, promote safety profile of the formulation and decrease undesirable side effects or potential citotoxicity. This work presents an overview of the selected ex vivo, in vivo and clinical investigations, systematized according to the chemical features of the incorporated phytoconstituent.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:760033
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-09-08 08:32:10