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master's thesis
Promjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. urn:nbn:hr:163:474739
Orehovački, Helena
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of biochemistry and molecular biology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Orehovački, H. (2019). Promjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:474739

Orehovački, Helena. "Promjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:474739

Orehovački, Helena. "Promjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:474739

Orehovački, H. (2019). 'Promjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:474739

Orehovački H. Promjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:474739

H. Orehovački, "Promjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:163:474739

Metadata
TitlePromjene N-glikanskih obrazaca imunoglobulina G i glikoproteina plazme uslijed ugradnje želučane premosnice
Title (english)N-glycosylation changes of plasma proteins and immunoglobulin G in bariatric surgery
AuthorHelena Orehovački
MentorGordan Lauc (mentor)
Committee memberGordan Lauc (predsjednik povjerenstva)
Committee memberMaja Ortner Hadžiabdić (član povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of biochemistry and molecular biology)
Zagreb
Defense date and country2019-09-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Pretilost i dijabetes tipa 2 metabolički su poremećaji i jedni od glavnih javnozdravstvenih problema današnjice. Prati ih stanje kronične upale organizma, međusobno su čvrsto povezani te predstavljaju glavne indikacije za provođenje kirurškog zahvata za liječenje debljine. Navedenom kirurškom intervencijom dolazi do dugotrajne remisije dijabetesa tipa 2 i naglog pada tjelesne mase. Promjene u ljudskom N-glikomu mogu biti specifične za određena stanja u organizmu te se N-glikane proučava kao potencijalne biljege bolesti, njene progresije i odgovora na terapiju. S ciljem utvrđivanja povezanosti patofizioloških promjena nakon operacije s promjenama N-glikozilacije, u ovom istraživanju analizirani su i uspoređeni N-glikanski profili imunoglobulina G i ukupnih glikoproteina plazme desetorice ispitanika prije ugradnje želučane premosnice i šest mjeseci nakon operativnog zahvata. Dobiveni rezultati pokazuju određene promjene u N-glikozilacijskom profilu ispitanika između navedenih vremenskih točaka, međutim, opažene razlike nisu dosegle statističku značajnost, najvjerojatnije zbog ograničenog broja ispitanika. Nadalje, opažene glikozilacijske promjene kreću se u suprotnom smjeru od onih koje se obično uočavaju u upalnim stanjima, što sugerira da je došlo do smanjenja razine upale nakon provedenog operacijskog zahvata. N-glikani imunoglobulina G i glikoproteina plazme time dobivaju ulogu potencijalnih dijagnostičkih i prognostičkih biomarkera za liječenje pretilosti i dijabetesa tipa 2 barijatrijskim zahvatom.
Abstract (english)
Obesity and type 2 diabetes are metabolic disorders which represent significant public healthcare burden globally. Both of them are associated with chronic low-grade inflammation, have a great interdependence and are the main indication for bariatric surgery. This procedure enables long-term type 2 diabetes remission and a significant loss of weight. Human N-glycome alterations can be specific for certain conditions, hence N-glycans are studied as potential prognostic markers for disease activity, progression and treatment. In order to determine associations between pathophysiological changes after surgery and alterations in N-glycosylation, we analyzed and compared immunoglobulin G and plasma glycoprotein N-glycan profiles from ten subjects, sampled at the baseline and six months after bariatric surgery. There was no statistically significant difference in N-glycome after the mentioned period, probably due to a limited number of examinees. According to the results, there are several clues that the reduction of inflammation has occurred among the patients. Immunoglobulin G and plasma glycoprotein N-glycans thereby show potential as diagnostic and prognostic biomarkers for bariatric treatment of obesity and type 2 diabetes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:474739
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-09-09 12:26:49