DNA as a basic molecule that transmits genetic information is subject to changes, and changes with pathogenic significance are called mutations that can ultimately affect the phenotype. Single nucleotide polymorphisms can affect gene expression and protein functionality during and after their synthesis, resulting in a specific genetic disorder. SNPs are detected by DNA sequence analysis, methods such as Sanger's dideoxy method, but also by GWAS studies and family studies, where DNA chips are used. During growth and development, in addition to endocrine regulation, local growth regulation is also important, and the aim of the research was to examine whether it is a monogenic disorder or short stature of the subject is result of polygenic effects. Research could also contribute to a better understanding of the interconnections of signaling pathways involved in growth and development as well as their genetic background in different tissues. A review of the literature and based on the obtained results, we are assuming that there is a multigenic effect and that in the background is cadherin 13 which shows the strongest association with genes at the level of the hypothalamus as a center for development. It is assumed that the influence of genes on bone development is locally present because we managed to connect the genes EHF and SPARC, but also WWTR1 and SMARCA4 (although we cannot claim with certainty the presence of SNPs) with RUNX2 which is one of the key factors of osteogenesis in the growth plate.