Analgesics are one of the most widely prescribed drugs among adult population. Significant number of potential drug-drug interactions refers to interactions of analgesics with other drugs. The incidence of interactions of analgesics is considered to be even higher because of their availability in OTC (over-the-counter) form. Prescription medication use is the most common in elderly even though some drugs, including some analgesics, are potentially inappropriate for older people. It is important to evaluate benefits and risks of analgesics use to avoid potential medication errors. Drug-drug interactions can be clinically important issue because they can cause medical complications. However, it is a medication error that can be prevented. It is important to assess clinical significance of potential drug interactions to avoid undesirable adverse events and possible consequences for the patient. Lexicomp Drug Interactions software is a useful tool that enables rapid screening of potential clinically significant drug-drug interactions. Also, it contains possible interventions and solutions to avoid or diminish potential consequences of drugs interactions. A total of 88 patients were included in this study, mostly elderly people. Mean age of the patients was 68 years. In 81,8% of the patients was found minimally one interaction of analgesics with other drugs. The majority of interactions of analgesics had clinical significance C (71,1%) and they mostly included potential interactions between NSAIDs and antihypertensive drugs. 28,4% of interactions of analgesics had clinical significance D and the most common possible consequence of these interactions was CNS depression. Only one patient had prescribed combination of two NSAIDs which was categorized as interaction with clinical significance X. Community pharmacist has a big role in patient education on rational and safe analgesics use. It is also necessary to assess drug-drug interactions during concomitant drug use.