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master's thesis
Lipid droplets in models of Parkinson's and stroke
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. urn:nbn:hr:163:831460
Sabol, Leo
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Sabol, L. (2021). Lipid droplets in models of Parkinson's and stroke (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:831460

Sabol, Leo. "Lipid droplets in models of Parkinson's and stroke." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:831460

Sabol, Leo. "Lipid droplets in models of Parkinson's and stroke." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:831460

Sabol, L. (2021). 'Lipid droplets in models of Parkinson's and stroke', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 16 February 2025, https://urn.nsk.hr/urn:nbn:hr:163:831460

Sabol L. Lipid droplets in models of Parkinson's and stroke [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2021 [cited 2025 February 16] Available at: https://urn.nsk.hr/urn:nbn:hr:163:831460

L. Sabol, "Lipid droplets in models of Parkinson's and stroke", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:163:831460

Metadata
TitleLipid droplets in models of Parkinson's and stroke
Title (croatian)Lipidne kapljice u modelima Parkinsonove bolesti i moždanog udara
AuthorLeo Sabol
MentorLidija Bach-Rojecky (mentor)
Committee memberLidija Bach-Rojecky (predsjednik povjerenstva)
Committee memberAna-Marija Domijan (član povjerenstva)
Committee memberSandra Šupraha Goreta (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2021-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Parkinson’s disease presents a great challenge in diagnose and treatment, as does stroke. Both require attention to improve these treatments and survivability. Somewhat new and uncharted territory in brain are lipid droplets. They are storage organelles as the pillar of lipid and energy homeostasis, but their function in brain is not yet absolutely defined and it could be of great influence. Goal of this thesis is to positively identify lipid droplets as active participants in neuroinflammation process regarding ischemic stroke and Parkinson’s disease using 6-OHDA models for Parkinson’s and three-vessel occlusion samples for ischemic stroke. Additionally, lipid droplets as participants in neuroinflammation are being identified in thapsigargin treated BV2 cells.
Abstract (english)
Parkinsonova bolest, kao i moždani udar, predstavlja ogromni problem kod dijagnostociranja i liječenja. Oba stanja zahtijevaju trenutnu pažnju za unaprijeđenje liječenja i smanjenje smrtnosti. Jedno od nedovoljno istraženih i novih dijelova tih bolesti su lipidne kapljice. One su, kao lipidni organeli, temeljni stupovi lipidne i energetske homeostaze, no njihova cjelovita uloga u mozgu nije još definirana i mogla bi biti od velikog značenja. Cilj ovog rada je sa sigurnošću identificirati lipidne kapljice kao aktivne sudionike upalnog procesa u mozgu tijekom Parkinsonove bolesti i ishemičnog moždanog udara koristeći modele 6-hidroksidopamina za Parkinsonovu bolest i uzorke sa trožilnom okluzijom za ishemični moždani udar. Također, identifikacija lipidnih kapljica kao aktivnih sudionika upalnih procesa u mozgu vrši se koristeći BV2 stanične culture tretirane s tapsigarginom.
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:163:831460
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-02-08 13:41:48