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master's thesis
Primjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. urn:nbn:hr:163:459876
Maričić, Anamaria
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Maričić, A. (2021). Primjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:459876

Maričić, Anamaria. "Primjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:459876

Maričić, Anamaria. "Primjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:459876

Maričić, A. (2021). 'Primjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:459876

Maričić A. Primjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2021 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:163:459876

A. Maričić, "Primjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:163:459876

Metadata
TitlePrimjena ciklodekstrina u poboljšanju in vitro brzine otapanja flufenaminske kiseline
Title (english)Application of cyclodextrins to enhance in vitro dissolution rate of flufenamic acid
AuthorAnamaria Maričić
MentorMario Jug (mentor)
Committee memberMario Jug (predsjednik povjerenstva)
Committee memberAnita Hafner (član povjerenstva)
Committee memberJasna Jablan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2021-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Fenamati su zanimljiva skupina nesteroidnih protuupalnih lijekova s obzirom da djeluju kao modulatori širokog spektra ionskih kanala i enzima. Zbog toga potencijalno predstavljaju zanimljive analgetike s drugačijim mehanizmom djelovanja. Unutar ove skupine, ističe se flufenaminska kiselina, koja se ubraja u II. skupinu lijekova prema BCS klasifikaciji, s obzirom da je niske topljivosti i visoke permeabilnosti. Zbog niske topljivosti u vodi je njena oralna bioraspoloživost niska što posljedično ograničava kliničku primjenu ovog lijeka. Na tržištu Europske unije dostupna je samo u Italiji kao topikalni pripravak za primjenu na kožu. Cilj ovoga rada je poboljšanje biofarmaceutskih karakteristika flufenaminske kiseline primjenom različitih ciklodekstrin. Istraživanje obuhvaća prirodni β-ciklodekstrin (β-CD) te njegove hidrofilne derivate hidroksipropil-β-ciklodekstrin (HP-β-C ), nasumično metilirani β-ciklodekstrin (RAMEB) te sulfobutileter-β-ciklodekstrin (SBE-β-CD). Binarni sustavi flufenaminske kiseline s ispitivanim ciklodekstinima pripremljeni su primjenom različitih tehnologija kojima je praćena brzina otapanja u in vitro uvjetima. Uzorci pripremljeni mljevenjem lijeka s HP-β-C te koevaporacijom s RAME pokazuju najviše potencijala u prevladavanja biofarmaceutski nepovoljnih karakteristika flufenaminske kiseline, u prvom redu ograničenog in vitro oslobađanja, koji ograničavaju širu terapijsku uporabu flufenaminske kiseline.
Abstract (english)
Fenamates are an interesting group of nonsteroidal anti-inflammatory drugs acting as modulators of a wide range of ion channels and enzymes. Therefore, they potentially represent interesting analgesics with a different mechanism of action. Within this group of drugs, flufenamic acid stands out, which belongs to the II. group of drugs according to the BCS classification, given its low solubility and high permeability. Due to its low aqueous solubility, its oral bioavailability is low and variable, which consequently limits the clinical use of this drug. It is only available on the European Union market in Italy as a topical preparation for application to the skin. This work aims to improve the biopharmaceutical properties of flufenamic acid by applying various cyclodextrins. The study includes natural β-cyclodextrin (β-CD) and its hydrophilic derivatives hydroxypropyl-β-cyclodextrin (HP-β-C ), randomly methylated β-cyclodextrin (RAMEB) and sulfobutylether-β-cyclodextrin (SBE-β-CD). Binary systems of flufenamic acid with tested cyclodextrins were prepared using various technologies that monitor the dissolution rate in vitro. Samples prepared by milling the drug with HP-β-CD and co-evaporating with RAMEB show the greatest potential in overcoming the biopharmaceutical unfavorable characteristics of flufenamic acid, primarily limited in vitro dissolution rate, which restricts the wider therapeutic use of that drug.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:459876
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-09-28
Terms of useLicence In copyright icon
Created on2022-02-28 11:39:11