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master's thesis
Nanoformulacije kurkumina s antimikrobnim djelovanjem
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. urn:nbn:hr:163:909075
Osmak, Lucija
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Osmak, L. (2021). Nanoformulacije kurkumina s antimikrobnim djelovanjem (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:909075

Osmak, Lucija. "Nanoformulacije kurkumina s antimikrobnim djelovanjem." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:909075

Osmak, Lucija. "Nanoformulacije kurkumina s antimikrobnim djelovanjem." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:909075

Osmak, L. (2021). 'Nanoformulacije kurkumina s antimikrobnim djelovanjem', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:909075

Osmak L. Nanoformulacije kurkumina s antimikrobnim djelovanjem [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2021 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:909075

L. Osmak, "Nanoformulacije kurkumina s antimikrobnim djelovanjem", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:163:909075

Metadata
TitleNanoformulacije kurkumina s antimikrobnim djelovanjem
Title (english)Curcumin nanoformulations with antimicrobial activity
AuthorLucija Osmak
MentorŽeljka Vanić (mentor)
Committee memberŽeljka Vanić (predsjednik povjerenstva)
Committee memberMario Jug (član povjerenstva)
Committee memberSanda Vladimir-Knežević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2021-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Kurkumin, polifenol izoliran iz biljke Curcuma longa, potencijalni je kandidat za terapiju različitih bolesti zahvaljujući svojem antimikrobnom, antikancerogenom i antioksidativnom učinku. Međutim, loša fizikalno-kemijska svojstva poput slabe topljivosti u vodi, lipofilnosti, kemijske nestabilnosti i loše bioraspoloživosti ograničavaju njegovu kliničku primjenu. Uklapanjem u nanoformulacije poput liposoma, nanočestica, micela, hidrogelova, nanokristala moguće je unaprijediti farmakokinetička i farmakodinamička svojstva kurkumina te time uvelike unaprijediti terapiju. Brojna istraživanja pokazala su da se uklapanjem kurkumina u nanoformulacije postiže bolja distribucija polifenola u organizmu, poboljšani terapijski učinak s ciljanom dostavom, ravnomjerno i kontrolirano oslobađanje na mjestu djelovanja, produljeno vrijeme eliminacije, povećanje bioraspoloživosti te smanjenje neželjenih učinaka i toksičnosti na zdravo tkivo. Provedena najvažnija ex vivo, in vivo i klinička istraživanja objedinjena ovim radom sistematizirano su opisana s obzirom na vrstu/tip nanoformulacija i svojstva materijala korištenih za njihovu pripravu.
Abstract (english)
Curcumin, a polyphenol isolated from the plant Curcuma longa, is a potential candidate for the treatment of various diseases due to its antimicrobial, anticancer and antioxidant effects. However, physicochemical properties of curcumin, such as poor water solubility, lipophilicity, chemical instability, and poor bioavailability limit its clinical application. Incorporation of curcumin into various nanoformulations (lipid and polymeric), can significantly improve its pharmacokinetic and pharmacodynamic properties, and thus significantly enhance the efficacy of therapy. Numerous studies have shown that curcumin nanoformulations allow better distribution of the polyphenol in the body, increased bioavailability, and therapeutic efficacy by enabling targeted and localized delivery, prolonged and/or controlled release at the site of action, decreased elimination time as well as reduced side effects and toxicity to the healthy tissue. The most important ex vivo, in vivo, and clinical studies included in this paper are systematically described with regard to the type of nanoformulations and the properties of the materials used for their preparation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:909075
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-07-16
Terms of useLicence In copyright icon
Created on2022-03-01 09:06:40