OBJECTIVES Due to lifestyle, an increasing number of people have subjective an/or objective symptoms of sensitive skin. Thea aim of proposed thesis is to cleary present and systematize the relevant evidence related to the positive or negative effects of ingredients and/or cosmetics formulations on causing skin sensitivity, which are important in the development of cosmetic products for sensitive skin. MATERIAL AND METHODS PubMed / Medline, Elsevier, Scopus and ResearchGate are used to create a thesis database. The keywords “sensitive skin”, “reactive skin”, “skin sensitization”, “contact sensitivity”, “skin sensitizers”, “dermocosmetic”, “cosmetic science”, “cosmetic technology”, “skin irritation”, “Formulating”, “ingredients”, “humectants”, “preservatives”, “surfactants”, “cleanser”, “emulsifier”, “solubilizers”, “UV filters” were used for the search separately and in combinations. All publications from search results with available full texts or with available abstracts were reviewed. The selection of scientific papers is limited to original scientific papers in English. Papers that meet the selected criteria were selected regardless of the date of their publication. The literature was searched from general to specialized articles, with selected articles relevant to the issue of specialist work. RESULTS Designing a cosmetic product for sensitive skin requires special attention. While specific irritant potential data are available for some groups of ingredients, some ingredients do not have them or are scarce. Using ingredients that have been used for a long time with a known and well-tested effect on the skin, adding the minimum required number of ingredients, testing the product before launch and monitoring customer feedback on side effects can ensure a safe and harmless product for sensitive skin. CONCLUSION Cosmetic products are part of people's daily hygiene, and due to the large number of people who have or consider to have sensitive skin, it is important to develop cosmetic products that are safe, perform their function, and do not contain ingredients that have irritating potential. When designing such a product, it is necessary to eliminate unnecessary ingredients from the product, remove all allergens and known irritants (or reduce their content), use appropriate antioxidants and avoid substances that increase the penetration of other ingredients into the skin. Preservatives and perfumes are the most common allergens in cosmetics. Proper selection of preservatives and omission of perfumes in the development of a cosmetic product for sensitive skin are key steps that reduce the possibility of irritation after using the product. The use of mild non-ionic and/or amphoteric surfactants and nourishing ingredients in a skin-like pH medium ensures gentleness and reduces the irritating potential of washes. After washing the skin, apply a moisturizer that should be formulated to contain an adequate ratio of lipids, occlusions and humectants (depending on the skin type), ingredients with low irritation potential and solvents that do not increase the penetration of other ingredients. If it is a cream with a sun protecting factor, the best choice are physical filters because, unlike chemical ones, they do not have any negative reactions on the skin. In addition to functional ingredients, cosmetic products may also contain active ingredients whose selection and the proportions used should be carefully selected. After the development of the cosmetic product, it is desirable to examine its irritating potential, and after entering the market to monitor the occurrence of adverse events in normal or reasonably predictable use.