Introduction: Depression is a public health mental disorder that affects more than 264 million people worldwide. Depressive disorders occur at any age, very often in people of younger age and more often females. Treatment is carried out with pharmacotherapy, psychotherapy, or a combination of both, and sometimes by other methods, such as electroconvulsive therapy. Despite numerous therapeutic options, a large number of patients do not achive therapeutic goals, and the disease is considered resistant to therapy. Given the complex pathophysiology of the disease and the uncertain outcome of treatment, a multidisciplinary approach and involvement of all stakeholders caring for the patient is important, with the role of the pharmacist as the most accessible health professional being of great importance. Objectives: The aim of this paper is to gain insight into the indications for which antidepressants are prescribed, and what are the attitudes of patients about the prescribed therapy. The observational study was conducted on a sample of patients who raise their therapy in PRIMA PHARMA Pharmacies. Based on the collected data, a specially created questionare will provide insight into the indications for which antidepressants are prescribed and assess the response, success, cooperation and satisfaction of patients with the prescribed therapy. Respondents and methods: Observational research in this study was conducted on 22 patients who in the period in which the study was conducted (August - October 2020) raised their therapy in the pharmacy and agreed to participate in the study. The research used a questionnaire created for the purposes of work that was recorded and examined: medical history, prescribed prescription drugs, over-the-counter preparations used by the patient, observed side effects and satisfaction with the prescribed therapy. Patients were asked for informed consent to participate in the study. The research was approved by Ethics Committee for Experimental Work of the Faculty of Pharmacy and Biochemistry, University of Zagreb. Results: In a sample of 22 subjects, 69% of them were diagnosed with depression, while 31% of subjects were prescribed antidepressants due to other indications. The most commonly prescribed antidepressants are escitalopram and sertraline, while venlafaxine is a somewhat less commonly prescribed drug. In addition to antidepressants, subjects have medications to treat other illnesses. Hypertension and hypothyroidism are the most commonly reported chronic diseases, while gastritis occurs as a result of taking larger amounts of medication. Some patients use hypnotics and anxiolytics for use as needed, most often due to sleep problems. By reviewing over-the-counter preparations, a smaller proportion of respondents use dietary supplements with magnesium and B vitamins. The answers to the questions covering the lifestyle of the respondents indicate that most people smoke cigarettes regularly (1-2 boxes a day), while alcohol is consumed occasionally. Side effects are reported by one respondent and relate to an increase in appetite. Conclusion: Although this research is based on a small number of patients, the results show that depression and other mental disorders carry with them a number of symptoms that need to be treated, but is also accompanied by different comorbidities, which requires a multidisciplinary and individual approach to each patient. The role of the pharmacist is extremely important in monitoring the outcomes of treatment since pharmacists are health professionals who prescribe the prescribed therapy, advise the patient, and monitor the outcomes of treatment. A prerequisite for quality patient care is constant education and personal development, as well as adaptation to patients with whom we are in daily contact