Objectives: The aim of this study was to review available literature data to determine the possibility of oral and topical application of probiotics in maintaining skin health and treatment of skin diseases, with special reference to particular probiotic strains. Materials and methods: For the purposes of this study, clinical studies, meta-analyzes and review articles were used. Data were obtained by searching the following databases: PubMed (Medline), Elsevier Science Direct, Scopus, Embase, and the Cochrane Library according to keywords (and their combinations): acne, atopic dermatitis, control of quality, dermatology, microbiom, prebiotics, probiotics, psoriasis, rosacea, skin reactivity, stability testing, topical probiotic. Results: Oral probiotic supplementation in adult patients and children diagnosed with atopic dermatitis has been shown to be beneficial in improving clinical symptoms such as itchy, dry, rough, and cracked skin. Perinatal and postnatal oral probiotic supplementation of high-risk mothers and their children has been shown to be a good choice in the prevention of atopic dermatitis / eczema and food allergies. Orally administered probiotics in combination with antibiotic therapy in the treatment of acne resulted in anti-inflammatory effect and reduced the side effects of antibiotic therapy. In patients diagnosed with psoriasis probiotics improve clinical symptoms, modulate microbiota composition and reduce the risk of disease relapse. Topically applied probiotics increased the level of ceramides in the epidermis of atopics and reduced inflammation, itching and dryness of the skin. Used in acne, toppicaly applied probiotics reduced the number of inflammatory lesions. They also accelerated the process of wound healing, by contributing to the formation of connective tissue and maintaining the balance of the skin microbiota. Conclusion: Some clinical studies shows that orally and topically applied probiotics excert positive effects in inflammatory skin conditions. Nevertheless, it should be taken into account that these are relatively small clinical trials that investigated the efficiency of different probiotic strains in different doses. Therefore the level of evidence for the efficiency of probiotics in skin diseases is low and there are still no official clinical guidelines for the use of probiotics in dermatology. Additional research is needed to determine the effectiveness of particular strains in adequate dosage regimes in maintaining skin health and treating different skin conditions.