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master's thesis
Inhibitori različitih protein-kinaza
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. urn:nbn:hr:163:099986
Slamić, Zrinka
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Slamić, Z. (2021). Inhibitori različitih protein-kinaza (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:099986

Slamić, Zrinka. "Inhibitori različitih protein-kinaza." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:099986

Slamić, Zrinka. "Inhibitori različitih protein-kinaza." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:099986

Slamić, Z. (2021). 'Inhibitori različitih protein-kinaza', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:099986

Slamić Z. Inhibitori različitih protein-kinaza [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2021 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:099986

Z. Slamić, "Inhibitori različitih protein-kinaza", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:163:099986

Metadata
TitleInhibitori različitih protein-kinaza
Title (english)Inhibitors of various protein kinases
AuthorZrinka Slamić
MentorKristina Pavić (mentor)
Committee memberKristina Pavić (predsjednik povjerenstva)
Committee memberZrinka Rajić (član povjerenstva)
Committee memberDavor Šakić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2021-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U ovom radu obrađeni su inhibitori receptora za epidermalni faktor rasta (EGFR) kao i inhibitori Bcr-Abl kinaze, fosfoinozitid-3-kinaze i Janus kinaze te inhibitori Hedgehog signalnog puta. U općem pregledu navedenih protein-kinaza istaknuti su bitni elementi svake skupine. Dan je uvid u signalni put svake navedene kinaze te pregled nekoliko odobrenih inhibitora na tržištu. Zatim je na konkretnim primjerima objašnjena struktura lijeka, važnost određenih dijelova strukture za djelovanje te je opisan sintetski put. Lijekovi obrađeni u ovom radu su: 1) inhibitori EGFR: neratinib i osimertinib, 2) Bcr-Abl inhibtori: nilotinib i ponatinib, 3) PI3K inhibitori: alpelisib i idelalisib, 4) JAK inhibitori: ruksolitinib i fedratinib, 5) Hedgehog inhibitori: sonidegib i vismodegib.
Abstract (english)
In this diploma thesis, epidermal growth factor receptor (EGFR) inhibitors, as well as BCR-Ab1 kinase, phosphoinositide-3-kinase, Janus kinase, and Hedgehog signaling pathway inhibitors, are discussed. The most important facts are highlighted for each protein kinase. An insight into the protein kinase signaling pathways and an overview of approved inhibitors are given. Furthermore, drug structures, structure-activity relationships, and synthetic routes are explained in specific examples. The following drugs are described in detail in this thesis: 1) EGFR inhibitors: neratinib and osimertinib, 2) Bcr-Abl inhibitors: nilotinib and ponatinib, 3) PI3K inhibitors: alpelisib and idelalisib, 4) JAK inhibitors: ruxolitinib and fedratinib, 5) Hedgehog inhibitors: sonidegib and vismodegib.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:099986
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-28 13:50:17