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master's thesis
Sinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. urn:nbn:hr:163:279351
Kučević, Anja
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Kučević, A. (2021). Sinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:279351

Kučević, Anja. "Sinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:279351

Kučević, Anja. "Sinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:163:279351

Kučević, A. (2021). 'Sinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:279351

Kučević A. Sinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2021 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:163:279351

A. Kučević, "Sinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:163:279351

Metadata
TitleSinteza i karakterizacija O-harmicina triazolskog tipa u položaju 7 β-karbolinskog prstena
Title (english)Synthesis and characterization of triazole type O-harmicines at the position 7 of the β-carboline ring
AuthorAnja Kučević
MentorZrinka Rajić (mentor)
Committee memberZrinka Rajić (predsjednik povjerenstva)
Committee memberIvana Perković (član povjerenstva)
Committee memberAna Mornar Turk (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2021-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Harmin i derivati cimetne kiseline su prirodni produkti koji pokazuju širok spektar bioloških djelovanja, među kojima su antimalarijsko i citostatsko djelovanje. Njihovim kovalentnim povezivanjem u hibridne spojeve, harmicine, nastoji se postići poboljšano djelovanje, smanjenje neželjenih učinaka i interakcija te smanjenje rezistencije na postojeću farmakoterapiju. U okviru ovog diplomskog rada sintetizirani su O-harmicini triazolskog tipa, 6a-e, korištenjem Cu(I) katalizirane alkin-azid cikloadicije. Usto, sintetizirani su i polazni spojevi, azidi derivata cimetne kiseline 3a-e i alkin 5. O-harmicini 6a-e su karakterizirani uobičajenim analitičkim i spektroskopskim metodama (talište, IR, 1H i 13C NMR, MS). U daljnjim istraživanjima sintetiziranim spojevima će biti ispitano citostatsko djelovanje na nizu tumorskih staničnih linija.
Abstract (english)
Harmine and cinnamic acid derivatives are natural products with a broad spectrum of biological activities, which includes antimalarial and cytotoxic effects. By their covalent binding to hybrid molecules, harmicines, improved action, reduction of side effects, drug interactions and resistance to existing pharmacotherapy might be achieved. In this thesis, O-harmicines of the triazole type 6a-e were synthesised using the Cu(I)-catalyzed dipolar alkyne-azide cycloaddition. Starting compounds, cynnamyl azides 3a-e and alkyne 5 were synthesized as well. Structures of O-harmicines were confirmed using conventional analytical and spectroscopic methods (melting point, IR, 1H and 13C NMR, MS). Further studies will focus on the evaluation of their cytotoxic activity against several cancer cell lines.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:279351
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-29 10:10:49