Pain, especially that of chronic duration, is a major public health problem because it is often inadequately treated due to its complex mechanism of occurrence and limited pharmacological possibilities. Modern therapy and guidelines for pain management are replacing the monomodal approach to multimodal treatment. Multimodal analgesia involves the administration of multiple drugs with different mechanisms of action acting at different sites along the nociceptive pathway. The synergistic or additive therapeutic effect of carefully selected drugs in combination allows the use of drugs in lower doses than individual, and better tolerability and safety, and reduces the need for high doses of opioid analgesics. Drugs used in combination are analgesics and drugs for which analgesia is not the primary function, and there are combinations of fixed doses of analgesics on the market. All these combinations have great potential in the treatment of pain and further research is needed on the multimodal approach and its use in practice, in order to better classify it in the category of successfully treated and / or successfully controlled health problems. Some of these combinations are also available over-the-counter and are used in the self-treatment of acute pain of various causes, with the pharmacist playing an important role. Proper education of patients and selection of the appropriate analgesic pharmacist can contribute to reducing the effectiveness of pain relief, the occurrence of adverse effects of drugs and prevent the development of complications of inappropriately treated pain.