prikaz prve stranice dokumenta Sinteza i karakterizacija harmicina karbamatnog tipa
Embargo period 2024-06-10
master's thesis
Sinteza i karakterizacija harmicina karbamatnog tipa
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. urn:nbn:hr:163:128070
Klarić, Karmela
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Klarić, K. (2022). Sinteza i karakterizacija harmicina karbamatnog tipa (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:128070

Klarić, Karmela. "Sinteza i karakterizacija harmicina karbamatnog tipa." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:163:128070

Klarić, Karmela. "Sinteza i karakterizacija harmicina karbamatnog tipa." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:163:128070

Klarić, K. (2022). 'Sinteza i karakterizacija harmicina karbamatnog tipa', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 14 May 2024, https://urn.nsk.hr/urn:nbn:hr:163:128070

Klarić K. Sinteza i karakterizacija harmicina karbamatnog tipa [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2022 [cited 2024 May 14] Available at: https://urn.nsk.hr/urn:nbn:hr:163:128070

K. Klarić, "Sinteza i karakterizacija harmicina karbamatnog tipa", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:163:128070

Metadata
TitleSinteza i karakterizacija harmicina karbamatnog tipa
Title (english)Synthesis and characterization of harmicines
AuthorKarmela Klarić
MentorZrinka Rajić (mentor)
Committee memberZrinka Rajić (predsjednik povjerenstva)
Committee memberIvana Perković (član povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2022-06-10, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Harmin i derivati cimetne kiseline pokazuju širok spektar farmakološkog djelovanja, među kojima je i antimalarijsko djelovanje. Njihovim povezivanjem nastaju harmicini te je cilj ovog rada bila sinteza i karakterizacija dva nova hibrida harmina i derivata cimetne kiseline povezana karbamatnom skupinom. Sintetski put uključivao je alkiliranje harmina i uklanjanje zaštitne skupine kako bi se dobio željeni amin 2, sintezu odgovarajućeg alkohola 5 te sintezu harmicina 6 i 7 pomoću CDI-a (Shema). Svim novosintetiziranim spojevima struktura je potvrđena uobičajenim analitičkim i spektroskopskim metodama (IR, 1H i 13C NMR, MS) te im je određena temperatura tališta. U daljnjim ispitivanjima, koja nadilaze okvir ovog rada, sintetiziranim derivatima ispitat će se antimalarijsko djelovanje.
Abstract (english)
Harmine and cinnamic acid derivatives (CAD) show a wide range of pharmacological activities, including antimalarial activity. Harmicines represent hybrids composed of harmine and CAD moieties and the aim of this thesis was the synthesis and characterization of two new carbamatetype harmicines. The synthetic pathway included alkylation of harmine and removal of the Bocprotecting group to obtain the desired amine 2, synthesis of the alcohol 5 and finally, synthesis of harmicines in the presence of CDI. The structures of the newly synthesized compounds were confirmed using conventional analytical and spectroscopic methods (IR, 1H i 13C NMR, MS) and their melting points were determined. Subsequent studies, which surpass this thesis, will determine antimalarial activity of the synthesized derivatives.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:128070
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2024-06-10
Terms of useLicence In copyright icon
Created on2022-07-06 11:22:44