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master's thesis
Imunoterapija dijabetesa tipa 1
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. urn:nbn:hr:163:182553
Lalić, Katarina
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medical biochemistry and haematology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Lalić, K. (2022). Imunoterapija dijabetesa tipa 1 (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:182553

Lalić, Katarina. "Imunoterapija dijabetesa tipa 1." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:163:182553

Lalić, Katarina. "Imunoterapija dijabetesa tipa 1." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:163:182553

Lalić, K. (2022). 'Imunoterapija dijabetesa tipa 1', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:182553

Lalić K. Imunoterapija dijabetesa tipa 1 [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2022 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:182553

K. Lalić, "Imunoterapija dijabetesa tipa 1", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:163:182553

Metadata
TitleImunoterapija dijabetesa tipa 1
Title (english)Immunotherapy of diabetes type 1
AuthorKatarina Lalić
MentorRoberta Petlevski (mentor)
Committee memberRoberta Petlevski (predsjednik povjerenstva)
Committee memberDonatella Verbanac (član povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Zagreb
Defense date and country2022-06-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract
Dijabetes tipa 1 (DT1) je autoimuna endokrinološka bolest koja nastaje kao posljedica uništenja β stanica gušterače koje proizvode hormon inzulin. Uzrokom razvoja DT1 smatra se kombinacija okolišnih i genetskih čimbenika koji dovode do autoimunosti posredovane u najvećoj mjeri autoreaktivnim T limfocitima. Trenutna terapija DT1 nadomjescima inzulina liječi posljedicu bolesti bez ostvarivanja učinka na očuvanje β stanica. Imunoterapija bi usmjeravanjem prema različitim sastavnicama imunosnog sustava mogla djelovati direktno na uzrok DT1. Najveći potencijal u održavanju remisije DT1 pokazuju teplizumab, alefacept i antitimocitni globulini, a djelovanje sva tri imunoterapijska pristupa usmjereno je prema sprječavanju aktivacije T limfocita. Unatoč pozitivnim rezultatima trenutno ni jedan oblik imunoterapije nije odobren za liječenje DT1.
Abstract (english)
Diabetes type 1 (DT1) is an autoimmune endocrine disease that results from the destruction of insulin producing pancreatic β cells. The cause of DT1 development is considered to be a combination of environmental and genetic factors that lead to autoimmunity mediated mostly by autoreactive T lymphocytes. Current DT1 insulin replacement therapy treats the consequences of the disease without having an effect on β cell preservation. Immunotherapy, by targeting different components of the immune system, could act directly on the cause of DT1. Teplizumab, alefacept and antithymocyte globulins show the greatest potential in maintaining DT1 remission, and the action of all three immunotherapeutic approaches is aimed at preventing T lymphocyte activation. Despite the positive results, currently no form of immunotherapy is approved for the treatment of DT1.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:182553
Study programmeTitle: Medical biochemistry
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra medicinske biokemije (magistar/magistra medicinske biokemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-07-14 15:43:09