Aim: The aim of this paper is to do a review of main drug-related problems in the treatment of patients with schizophrenia and depression and to make a reference to the importance of the role that pharmacists could have in their managment. Subjects and method: For this purpose relevant psychiatric diagnostic manuals, currently relevant treatment guidelines, scientific articles and expert perspectives, publications of professional associations and institutions, Agency for Medicinal Products and Medical Devices' database and other available resources were searched. Results: Three main drug-related problems in the treatment of patients with schizophrenia and depression were identified, that may have a negative impact on preferred treatment outcome: adverse drug reactions of psychotropic medications, poor medication adherence and use of multiple medication which creates a potential for drug-drug interactions and medication errors. Conclusion: Drug-related problems should be identified and managed or prevented in timely manner in order to achieve the therapeutic goal. Pharmacists, as the link between a physician and a patient, are found to be in an ideal position for intervention in identified drug-related problems with potential of contribution in better treatment outcome. Therefore, there is a need for greater involvement of pharmacists in mental health care and also a need for monitoring of its effects.