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professional thesis
Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. urn:nbn:hr:163:947493
Naletilić, Marjana
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacognosy

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Naletilić, M. (2022). Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože (Professional thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:947493

Naletilić, Marjana. "Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože." Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:163:947493

Naletilić, Marjana. "Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože." Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2022. https://urn.nsk.hr/urn:nbn:hr:163:947493

Naletilić, M. (2022). 'Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože', Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:947493

Naletilić M. Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože [Professional thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2022 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:163:947493

M. Naletilić, "Biljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože", Professional thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:163:947493

Metadata
TitleBiljni ekstrakti i sekundarni metaboliti u tretmanu hiperpigmentacije kože
AuthorMarjana Naletilić
MentorMarijana Zovko Končić (mentor)
Committee memberSanda Vladimir-Knežević (predsjednik povjerenstva)
Committee memberMarijana Zovko Končić (član povjerenstva)
Committee memberMaja Lusina Kregar (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacognosy)
Zagreb
Defense date and country2022-07-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Cilj istraživanja Poremećaji pigmentacije kože sve su češći estetski problem. Zlatni standard terapije je dugo bio hidrokinon, ali se zbog njegovih nuspojava i dugoročne sigurnosti, intenzivno istražuju biljni ekstrakti i sekundarni metaboliti koji se u njima nalaze. Cilj rada je pregled i sistematizacija rezultata istraživanja biljnih ekstrakata i sekundarnih metabolita koji se koriste u pripravcima za terapiju hiperpigmentacije kože te procjena učinkovitosti i opravdanosti njihove primjene. Materijal / Ispitanici i metode Za potrebe pisanja pretražene su relevantne bibliografske baze podataka. Pretragom su obuhvaćeni izvorni znanstveni radovi, prvenstveno kliničke studije, koje su ispitivale terapiju hiperpigmentacije biljnim ekstraktima te biljnim sekundarnim metabolitima, a koje imaju dostupne cjelovite tekstove ili iznimno sažetke. Odabir znanstvenih radova je bio ograničen na one objavljene na engleskom jeziku. Radovi koji su odgovarali kriterijima bili su odabrani neovisno o datumu njihove objave. Rezultati Studije uključene u ovaj rad pokazale su da su biljni ekstrakti učinkoviti u terapiji hiperpigmetacije. U rad su uvrštene kliničke studije koje su ispitivale učinak aloe vere, indijskog ogrozda, sjemenki grožđa, biljne vrste Klasea quinquefolia, orhideje Brassocattleya marcella, peršina, primorskog bora, riže, sladića, štavelja i tratinčice, te sekundarnih metabolita poput aloesina, kojične kiseline, glabridina i β-arbutina. Među navedenim biljnim ekstraktima i sastavnicama najbolje su ispitani arbutin i kojična kiselina. Biljne opcije dovele su do smanjenja veličine i intenziteta hiperpigmentacijskih mrlja, uz djelotvornost koja se može usporediti s hidrokinonom, ali s manje nuspojava. Zaključak Biljni ekstrakti i sekundarni metaboliti obuhvaćeni ovim radom pokazali su značajan učinak u tretmanu hiperpigmentacija. Unatoč tomu, potrebna su dodatna ispitivanja uz dugoročno praćenje pacijenata i nakon prestanka upotrebe terapije, što će pridonijeti boljem uvidu u učinkovitost i sigurnost njihove primjene.
Abstract (english)
Objectives Skin pigmentation disorders are an increasingly common aesthetic problem. The gold standard of therapy has long been hydroquinone, but due to its side effects and long-term safety, plant extracts and secondary metabolites are intensively investigated. The aim of this work is to review and systematize the results of research of plant extracts and secondary metabolites used in products for skin hyperpigmentation and to assess the effectiveness and justification of their application. Material and Methods For preparation of this work relevant bibliographic databases have been searched. The study included original scientific papers, primarily clinical trials, which examined the therapy of hyperpigmentation with herbal extracts and plant secondary metabolites. The studies with available full texts or exceptionally summaries were included. The selection of scientific papers was limited to those published in English. Papers that matched the criteria were selected regardless of the date of their publication. Results Studies included in this work have demonstrated that herbal extracts are effective in therapy of hyperpigmentation. Clinical studies done on Aloe vera, Indian gooseberry, grapevine seed, plant species Klasea quinquefolia, orchid Brassocattleya marcella, parsley, maritime pine, rice, licorice, amla and daisy, as well as secondary metabolites such as aloesin, kojic acid, glabridin and β-arbutin have been included. Among the aforementioned plant extracts and metabolites arbutin and kojic acid were included in the greatest number of studies. Herbal options have led to a decrease in the size and intensity of hyperpigmentation spots, with efficacy comparable to hydroquinon but with fewer side effects. Conclusions Herbal extracts and secondary metabolites have shown a significant effect in the treatment of hyperpigmentation. However, additional trials with long-term monitoring even cessation of therapy, are needed for better insight into their efficacy and safety.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:947493
Study programmeTitle: Dermopharmacy and cosmetology
Study programme type: university
Study level: postgraduate specialist
Academic / professional title: sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije (sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-09-09 13:26:16