Cluster headache is the most painful primary headache that is included in trigeminal autonomic cephalgias (TACs). It is characterized by strong unilateral attacks that occur in clusters between periods of remission. The pain attack lasts 15 to 180 minutes and is accompanied by lacrimation, rhinorrhea and redness of the eye. Depending on the duration of the remission between attacks, cluster headache is divided into episodic and chronic cluster headache. The pathophysiology of cluster headache is complicated and not yet fully understood. According to current knowledge, the trigeminovascular system, the autonomic system and the hypothalamus are involved in the pathogenesis of cluster headaches. Neuropeptides such as CGRP, PACAP-38 and VIP are also an important part of pathogenesis. Treatment of cluster headache can be aimed at terminating an acute attack or at preventing it. Oxygen and triptans are most often used for acute treatment, while verapamil and lithium are used for prophylactic treatment. Corticosteroids were shown useful at the onset of episodic cluster headache until long-term prevention becomes effective. Galcanezumab was shown effective in the prophylactic treatment of patients with episodic cluster headache. Neurostimulation techniques such as non-invasive vagus nerve stimulation, deep brain stimulation, sphenopalatine ganglion stimulation and invasive occipital nerve stimulation also play an important role in treatment and prevention. The goal of acute treatment of cluster headache is to relieve symptoms and shorten the duration of pain, while preventive treatment aims to reduce the frequency of attacks, as well as their intensity. To achieve the desired therapeutic goals, it is necessary to educate patients with cluster headaches about the disease itself and the proper use of medications. This is exactly where pharmacists play an important role as educated mediators between doctors and patients.