Objectives: The aim of this paper is to determine the safety of statin therapy because it is widely used in the general population, and may have side effects that impair quality of life. Material: For this purpose, relevant scientific and professional literature, publications of professional institutions and other available sources were reviewed. Results: Statins are often associated with serious psychological side effects such as: impaired cognitive function, development of dementia and depression, aggressive behavior. There are studies that support these claims, but also, there are studies that have given the opposite results. Most cognitive side effects have been reported with atorvastatin and simvastatin, probably due to their lipophilicity and ability to cross the blood-brain barrier. In people with Alzheimer's dementia and normal cholesterol levels, simvastatin treatment had no effect on worsening the symptoms of the disease. Only simvastatin may be marginally associated with an increase in depressive symptoms, although the quality of the evidence to support this is low. Many studies have shown that low serum cholesterol levels have been found in people with aggressive behavioral disorders and in those individuals who have attempted suicide. Conclusion: There are conflicting research results on the effect of statins on cognitive function. Statins do not delay cognitive deterioration in patients with known dementia. Psychiatric effects associated with statins are rare and do not prevent possible events that are most likely to occur in susceptible patients with subclinical neurotransmitter pathway impairment. Assumptions were not confirmed in most studies that were to investigate certain psychological side effects. The potential limitations of these studies represent the variability of the criteria adopted to measure endpoints, based on a large number of different parameters and questionnaires for the assessment of neuropsychiatric disorders. Some of these tools may not be appropriate for identifying that events. Most of the studies involved were conducted on small populations and could not have enough strength to assess the risk of such rare events.