Purpose of the research: The aim of this work was to determine the real potential of counseling by a pharmacist for people suffering from stress-related mental disorders in the Republic of Croatia, with the exception of falling asleep and sleep-through disorders. This work presents the OTC medicines and food supplements (except of homeopathic products) currently available to a Croatian pharmacist for this purpose. Subjects and methods: This specialist paper is based on scientific and professional literature from fields of medicine and (phyto)pharmacy. The research articles collected are the result of a search in databases such as Pubmed, ScienceDirect and Google Scholar, while the websites of institutions such as the European Medicines Agency and the Croatian Agency for Medicinal Products and Medical Devices were also used as important sources of information. Results: A pharmacist in a public pharmacy in the Republic of Croatia could recommend to a patient one of only three OTC available medications for self-treatment of the psychological effects of stress on the organism. The number of food supplements and aromatherapy products that can provide good support for maintaining mental health is far greater. Very few products are available to pharmacists for self-treatment of patient groups such as children or pregnant/ breastfeeding women. Conclusion: There are a variety of psychological effects of stress on the organism. Individuals who decide to seek help often first consult a community pharmacist, who is expected to determine through effective communication whether or not self-treatment is safe for these patients and, if deemed safe, recommend the use of certain OTC medicines or food supplements. Aromatherapy, adaptogens and probiotics are often underutilized options for effective stress relief. Their timely, safe and effective use depends largely on the competencies of the pharmacist, who must continually acquire new professional knowledge and skills.