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master's thesis
Izrada i karakterizacija nanosuspenzija loteprednol etabonata
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. urn:nbn:hr:163:430774
Špoljar, Andrija
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Špoljar, A. (2023). Izrada i karakterizacija nanosuspenzija loteprednol etabonata (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:430774

Špoljar, Andrija. "Izrada i karakterizacija nanosuspenzija loteprednol etabonata." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:430774

Špoljar, Andrija. "Izrada i karakterizacija nanosuspenzija loteprednol etabonata." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:430774

Špoljar, A. (2023). 'Izrada i karakterizacija nanosuspenzija loteprednol etabonata', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:430774

Špoljar A. Izrada i karakterizacija nanosuspenzija loteprednol etabonata [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2023 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:163:430774

A. Špoljar, "Izrada i karakterizacija nanosuspenzija loteprednol etabonata", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:163:430774

Metadata
TitleIzrada i karakterizacija nanosuspenzija loteprednol etabonata
Title (english)Preparation and charachterization nanosuspension of loteprednol etabonate
AuthorAndrija Špoljar
MentorIvan Pepić (mentor)
Committee memberIvan Pepić (predsjednik povjerenstva)
Committee memberAnita Hafner (član povjerenstva)
Committee memberJasna Jablan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2023-06-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U ovom eksperimentalnom diplomskom radu izrađene su nanosuspenzije loteprednol etabonata uz dodatak površinski aktivne tvari SoluPlusa® metodom vlažnog mljevenja. Vlažno mljevenje je provedeno u ampulama uz dodatak kuglica itrij stabiliziranog cirkonijevog oksida i magnetskih mješača na višekanalnom mješaču pri sobnoj temperaturi brzinom od 350 okretaja u minuti. Ispitivan je i utjecaj vremena vlažnog mljevenja na veličinu čestica nanosuspenzije loteprednol etabonata kao bitnog procesnog parametra. Karakterizacija nanosuspenzija provedena je metodom fotonske korelacijske spektroskopije i transmisijskom elektronskom mikroskopijom. Izrađivane su micele SoluPlusa® u pročišćenoj vodi i u fosfatnom puferu s ciljem ispitivanja utjecaja pH na veličinu micela. Ishodne mikrosuspenzije loteprednol etabonata prosječne su veličine čestica više od 3000 nm, dok su nanokristali izrađeni vlažnim mljevenjem prosječne veličine čestica oko 180 nm, a indeks polidisperznosti nanosuspenzija iznosila je u prosjeku oko 0,4. Nanosuspenzijama je ispitivana stabilnost u vremenskom razdoblju od 7 dana. Izrađene nanosuspenzije su pokazale nestabilnost kroz taloženje i agregiranje čestica nanokristala te su bile mliječno bijele boje.
Abstract (english)
In this experimental thesis, nanosuspensions of loteprednol etabonate were prepared with the addition of the surfactant SoluPlus® using the wet milling method. Wet millin was performed in ampoules with the addition of a ball of yttrium stabilized zirconium oxide and magnetic stirrers on a multichannel mixer at room temperature at a speed of 350 revolutions per minute. The influence of wet milling time on the particle size of loteprednol etabonate nanosuspension was also examined as an important process parameter. The characterization of the nanosuspension was carried out by the method of photon correlation spectroscopy and transmission electron microscopy. SoluPlus® micelles were made in purified water and in phosphate buffer in order to test the effect of pH on the micelle size. The resulting loteprednol etabonate microsuspensions have an average particle size of more than 3000 nm, while the nanocrystals produced by wet milling have an average particle size of about 180 nm, and the polydispersity index of the nanosuspension was on average about 0.4. Nanosuspensions were tested for stability over a period of 7 days. The prepared nanosuspensions showed instability through precipitation and aggregation of nanocrystal particles and were milky white in color.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:430774
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-01-04 15:00:22