Text Inflammatory bowel diseases are a group of autoimmune diseases characterized by chronic or relapsing inflammatory conditions in the gastrointestinal tract. The increasing incidence and prevalence of these diseases in the general population are concerning because they seriously compromise the quality of life of patients and present numerous challenges for healthcare Due to the challenging and prolonged treatment, patients with inflammatory bowel diseases often turn to dietary supplements. As the number of patients using these supplements is growing, it is important to investigate their effectiveness and safety. The aim of this work was to conduct a physicochemical characterization of herbal dietary supplements used in the therapy of inflammatory bowel diseases according to the USP protocols. 36 samples were tested in various dosage forms: tablets, powders, hard capsules and soft capsules. The following tests were carried out: bulk density and tapped density (USP <616>), weight variation of dosage forms (USP <2091>), disintegration (USP <2040>), soft capsule rupture (USP <2040>), tablet friability (USP <1216>) and tablet breaking force (USP <1217>).The raw materials of turmeric have the best flow properties, according to tapped density testing, among the tested powder samples, while the andrographis samples have the least desirable flow properties. All tested tablets and capsules passed the USP weight variation test. Only one sample did not meet the disintegration criteria. In the soft capsule rupture and tablet friability testing, all samples met the USP criteria. Tablet breaking force was in the range from 27.7 to 248.5N. Poor raw material flow characteristics can cause unequal dosing units, while a tablet that did not disintegrate is unlikely to be effective in vivo.