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master's thesis
Potencijal kratoma u liječenju nociceptivne boli
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. urn:nbn:hr:163:708395
Mijić, Kristina
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacognosy

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Mijić, K. (2023). Potencijal kratoma u liječenju nociceptivne boli (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:708395

Mijić, Kristina. "Potencijal kratoma u liječenju nociceptivne boli." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:708395

Mijić, Kristina. "Potencijal kratoma u liječenju nociceptivne boli." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:708395

Mijić, K. (2023). 'Potencijal kratoma u liječenju nociceptivne boli', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:708395

Mijić K. Potencijal kratoma u liječenju nociceptivne boli [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2023 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:708395

K. Mijić, "Potencijal kratoma u liječenju nociceptivne boli", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:163:708395

Metadata
TitlePotencijal kratoma u liječenju nociceptivne boli
Title (english)The potential of kratom in the treatment of nociceptive pain
AuthorKristina Mijić
MentorMarijana Zovko Končić (mentor)
Committee memberMarijana Zovko Končić (predsjednik povjerenstva)
Committee memberMaja Bival Štefan (član povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacognosy)
Zagreb
Defense date and country2023-09-08, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Kratom je biljka s dugom povijesti tradicijskog korištenja kod brojnih stanja pri čemu je često droga izbora za samoliječenje boli. Cilj ovog diplomskog rada je bio prikupiti relevantne pretkliničke in vivo i kliničke studije koje su proučavale analgetsko djelovanje ekstrakata kratoma, njegovih alkaloida (mitragina, 7-hidroksimitraginina) i polusintetskih derivata, razjasniti mehanizam djelovanja i procijeniti ima li potencijal da postane novi legalni analgetik. Zbog uočene povezanosti dugotrajne primjene kratoma s razvojem ovisnosti, diplomski rad je baziran samo na liječenju boli nociceptivnog tipa. Sve studije koje su uključene u diplomski rad su potvrdile kako ekstrakti, izolirani alkaloidi i njihovi polusintetski derivati kratoma posjeduju analgetska svojstva. Ovim sustavnim pregledom je ustanovljeno da su analgetski učinci posredovani uglavnom opioidnim sustavom i da to može postati sigurnosti problem kod primjene. Unatoč tome, ovaj rad nudi dokaze da postoji potencijal da jedan od alkaloida kratoma ili pak spoj polusintetiziran iz tih alkaloida postane analgetik koji bi bio učinkovitiji i sigurniji u odnosu na morfin.
Abstract (english)
Kratom is a plant with a long history of traditional use for numerous conditions, often being the drug of choice for self-treatment of pain. The aim of this thesis was to collect relevant preclinical in vivo and clinical studies that investigated the analgesic effect of kratom extracts, its alkaloids (mitragynine, 7-hydroxymitragynine) and semi-synthetic derivatives, clarify the mechanism of action and assess whether it has the potential to become a new legal analgesic. Due to the observed association of long-term use of kratom with the development of addiction, the thesis is based only on the treatment of pain of the nociceptive type. All studies that are included in the thesis confirmed that extracts, isolated alkaloids and their semi-synthetic derivatives of kratom possess analgesic properties. In this systematic review, it was found that the analgesic effects are mediated mainly by the opioid system and that this may become a safety issue in administration. Nevertheless, this thesis offers evidence that there is a potential for one of the kratom alkaloids or a compound semi-synthesized from these alkaloids to become an analgesic that would be more effective and safer than morphine.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:708395
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-01-24 14:59:29