prikaz prve stranice dokumenta Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci
Embargo period 2025-09-13
master's thesis
Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. urn:nbn:hr:163:934053
Fruk, Tamara
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of analytical chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Fruk, T. (2023). Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:934053

Fruk, Tamara. "Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:934053

Fruk, Tamara. "Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:934053

Fruk, T. (2023). 'Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:934053

Fruk T. Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2023 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:163:934053

T. Fruk, "Analiza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:163:934053

Metadata
TitleAnaliza farmaceutskih proizvoda rendgenskom fluorescencijskom spektroskopijom s totalnom refleksijom: osnovni principi i analitički postupci
Title (english)Total reflection X-ray fluorescence analysis of pharmaceutical products: basic principles and analytical procedures
AuthorTamara Fruk
MentorJasna Jablan (mentor)
Committee memberJasna Jablan (predsjednik povjerenstva)
Committee memberSuzana Inić (član povjerenstva)
Committee memberMaja Bival Štefan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of analytical chemistry)
Zagreb
Defense date and country2023-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Elementarna onečišćenja mogu dospjeti u farmaceutski proizvod u raznim fazama njegovog razvoja, transporta i skladištenja te utjecati na djelatnu tvar, stabilnost farmaceutskog proizvoda ili sama imati neželjene učinke na ljudsko zdravlje. Zbog toga je elementarna analiza ovakvih uzoraka i određivanje elementarnih onečišćenja od velikog značaja te postoji potreba za brzim i osjetljivim analitičkim tehnikama koje se mogu koristiti za takve analize. Uz to, teži se da tehnike slijede načela „zelene kemije“. U tom smislu, TXRF se nameće kao jedna važna tehnika za kvalitativnu i kvantitativnu elementarnu analizu. TXRF je spektroskopska tehnika koja se temelji na principu totalne refleksije rendgenskih zraka, a zbog male količine uzorka potrebnog za analizu, IUPAC definira TXRF kao tehniku mikroanalize. Znanstvena istraživanja o primjeni TXRF tehnike u analizi farmaceutskih uzoraka kao što su djelatne tvari, lijekovi i dodaci prehrani pokazuju potencijal njezine primjene za analizu takvih uzoraka, a kod TXRF tehnike vidljiva je primjena načela zelene kemije jer je za analizu potrebna mala količina uzorka i reagensa, smanjena je uporaba štetnih kemikalija i količine energije te se stvara manje štetnog otpada.
Abstract (english)
Elemental impurities may enter the pharmaceutical product at various stages of development, transportation and storage and may affect the active pharmaceutical ingredient and stability of the pharmaceutical product or have adverse effects on human health. For this reason, elemental analysis of these samples and the determination of elemental impurities is of great importance, and there is a need for fast and sensitive analytical techniques that can be used for such analysis. Moreover, the methods should comply with the principles of "green chemistry". In this sense, TXRF is presented as one important technique for qualitative and quantitative elemental analysis. TXRF is a spectroscopic technique based on the principle of total reflection of X-rays. Because a small amount of sample is required for analysis, IUPAC defines TXRF as a microanalysis technique. Scientific studies on the application of TXRF technique in the analysis of pharmaceutical samples such as active pharmaceutical ingredients, drugs and dietary supplements demonstrate the potential of its use in the analysis of such samples. The application of „green chemistry“ principles to the TXRF technique is evident in the small amount of samples and reagents required for analysis, the use of less harmful chemicals and energy and the generation of less harmful waste.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:934053
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-09-13
Terms of useLicence In copyright icon
Created on2024-01-25 13:28:03