prikaz prve stranice dokumenta Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici
Embargo period 2025-10-26
master's thesis
Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. urn:nbn:hr:163:777015
Cvetko, Josip
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacognosy

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Cvetko, J. (2023). Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:777015

Cvetko, Josip. "Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:777015

Cvetko, Josip. "Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:777015

Cvetko, J. (2023). 'Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 14 May 2024, https://urn.nsk.hr/urn:nbn:hr:163:777015

Cvetko J. Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2023 [cited 2024 May 14] Available at: https://urn.nsk.hr/urn:nbn:hr:163:777015

J. Cvetko, "Ispitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:163:777015

Metadata
TitleIspitivanje biološke aktivnosti ekstrakata primorskog vriska (Satureja montana L.) bogatih flavonoidima za primjenu u fitofarmaciji i kozmetici
Title (english)Examination of the biological activity of extracts of winter savory (Satureja montana L.) rich in flavonoids for use in phytopharmacy and cosmetics
AuthorJosip Cvetko
MentorMarijana Zovko Končić (mentor)
Committee memberMarijana Zovko Končić (predsjednik povjerenstva)
Committee memberMaja Bival Štefan (član povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacognosy)
Zagreb
Defense date and country2023-10-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Izgledu i zdravlju ljudske kože oduvijek se obraćala velika pozornost i briga. Oksidativni stres, starenje, sunčeve UV zrake i upalne bolesti epidermisa i dermisa uzokuju neželjene promjene ljudske kože koje se liječe i ispravljaju kozmetičkim pripravcima. Trenutno postojeće sastavnice kozmetičkih proizvoda imaju mogućnost ispoljavanja nuspojava pa postoji potreba za otkrivanjem novih terapijskih mogućnosti iz prirodnih izvora. Ekstrakti primorskog vriska dobiveni ekstrakcijom s glicerolom i HP-β-CD sadrže visoke koncentracije flavonoida i posebice luteolin-7-O-glukozida. U ispitivanjima biološke aktivnosti ekstrakti su ostvarili izvrsnu antioksidativnu aktivnost (ispitanu pomoću DPPH metode i redukcijske snage) i protuupalno djelovanje (određeno ispitivanjem inhibicije lipoksigenaze i denaturacije ovalbumina). Također, ispitana je inhibitorna aktivnost ekstrakata na enzimima ljudske kože tirozinazi, elastazi i hijaluronidazi. Dok za tirozinazu i elastazu ekstrakti nisu ostvarili značajan stupanj inhibicije, ekstrakti su uspješno inhibirali enzim hijaluronidazu. Zahvaljujući tome, ekstrakti vrste S. montana mogu se razmotriti kao potencijalne nove komponente u budućim kozmetičkim pripravcima namijenjenima očuvanju zdravlja i postizanju željenog izgleda kože.
Abstract (english)
Great attention and care have always been paid to the appearance and health of human skin. Oxidative stress, aging, the sun's UV rays and inflammatory diseases of the epidermis and dermis cause unwanted changes in human skin that are treated and corrected with cosmetic preparations. The currently existing components of cosmetic products have the possibility of side effects, so there is a need to discover new therapeutic possibilities from natural sources. Winter savory extracts obtained by extraction with glycerol and HP-β-CD contain high concentrations of flavonoids and luteolin-7-O-glucoside in particular. In biological activity tests, the extracts achieved excellent antioxidant activity (tested by DPPH method and reducing power) and anti-inflammatory activity (determined by lipoxygenase inhibition and ovalbumin denaturation tests). The inhibitory activity of extracts on human skin enzymes tyrosinase, elastase and hyaluronidase was also tested. While the extracts did not achieve a significant degree of inhibition of tyrosinase and elastase, they successfully inhibited the enzyme hyaluronidase. Thus, the extracts obtained from S. montana can be considered as potential new components in future cosmetic preparations intended to preserve health and achieve the desired appearance of the skin.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:777015
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-10-26
Terms of useLicence In copyright icon
Created on2024-01-25 13:54:34