Objectives: The primary goal of this research is to determine patient satisfaction with pharmacotherapy used for the treatment of type 2 diabetes and to determine the antidiabetic drugs that contributed to greater patient satisfaction with type 2 diabetes treatment according to the results of the DTSQ. The secondary goal of the research is to determine how other parameters (socio-demographic, clinical, anthropometric and adherence) affect the satisfaction of patients with type 2 diabetes treatment. Patients and methods: This cross-sectional study was conducted at the level of primary health care in the Gradska ljekarna Zagreb, Šestinska cesta 1, Zagreb from December 2022 to February 2023. 50 patients were included in the study. Inclusion criteria for participation in the study were age of 18 years and older, type 2 diabetes diagnosed at least 3 months ago and signed informed consent. For the purpose of data collection, a form consisting of 2 parts was used. The first part of the form was created for the needs of the work and it records: socio-demographic characteristics of patients (age, gender, level of education, work and marital status, lifestyle habits), anthropometric measurements (height, body mass, body mass index), clinical characteristics of patients (fasting blood glucose value, HbA1c, complications of diabetes, comorbidities, duration of diabetes and therapy for the treatment of diabetes) and adherence to medication. The second part of the data collection form is the DTSQ, which measures patient satisfaction with diabetes treatment. Descriptive statistics were used to analyze the existence of a connection between satisfaction with the treatment of type 2 diabetes as determined by the DTSQ and socio-demographic and clinical characteristics of patients and adherence determined in the first part of the data collection form. The data were analyzed with the statistical program TIBCO Statistica v.13 (TIBCO Software Inc., California, USA). Results: The average value of the DTSQ score was 31,16 ± 4,36. Considering the size of the sample and the type of pharmacotherapy, the patients were divided into 4 groups: the first group used only oral antidiabetics, the second group used oral antidiabetics as well as insulin, the third group used oral antidiabetics and GLP-1 agonists (subcutaneous administration), while the fourth group, in addition to oral antidiabetics, used insulin and GLP-1 agonists (subcutaneous administration). The results by group were: Group 1 (31,06 ± 4,64), Group 2 (30,80 ± 4,76), Group 3 (32,10 ± 3,07), Group 4 (29,00 ± 7,07). No statistical significance was determined between these groups regarding the influence on the DTSQ score (ANOVA test ; F=0,32 ; P=0,810). Of the other parameters that were examined, statistical significance was only established for the duration of diabetes (ANOVA test ; F=4,21 ; P=0,021), glycated hemoglobin value (T-test ; t=3,61 ; P<0,001) and perceived hypoglycemia (Pearson's correlation coefficient ; r=-0,31 ; P=0,026). Conclusion: Through the DTSQ questionnaire, it was not established that certain types of pharmacotherapy statistically significantly result in increased patient satisfaction compared to others. These results are in favor of individualized treatment of type 2 diabetes, and of the parameters for which statistical significance was established, when choosing pharmacotherapy, the caution is required due possibility of inducing hypoglycemia, which in our patients statistically significantly impaired satisfaction with treatment. The glycated hemoglobin value, in addition to being an indicator of glycemic control, can also serve as a parameter that suggests satisfaction with pharmacotherapy. Considering the duration of diabetes, more attention should be paid to patients in the eventual modification of pharmacotherapy or the treatment of accompanying comorbidities so that the satisfaction with treatment is not impaired over time.