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master's thesis
Povezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. urn:nbn:hr:163:968411
Crneković, Juraj
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Crneković, J. (2023). Povezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:968411

Crneković, Juraj. "Povezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:968411

Crneković, Juraj. "Povezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:968411

Crneković, J. (2023). 'Povezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 05 May 2024, https://urn.nsk.hr/urn:nbn:hr:163:968411

Crneković J. Povezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2023 [cited 2024 May 05] Available at: https://urn.nsk.hr/urn:nbn:hr:163:968411

J. Crneković, "Povezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:163:968411

Metadata
TitlePovezanost Val66Met i C270T polimorfizama gena za moždani neurotrofni čimbenik (BDNF) i koncentracije BDNF-a u plazmi s depresijom, težinom simptoma i odgovorom na terapiju
Title (english)The association of Val66Met and C270T polymorphisms in the gene coding for brain derived neurotophic factor (BDNF) and BDNF plasma concentration with depression, severity of symptoms and treatment reponse
AuthorJuraj Crneković
MentorDubravka Švob Štrac (mentor)
MentorLidija Bach-Rojecky (mentor)
Committee memberDubravka Švob Štrac (predsjednik povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
Committee memberMatea Nikolac Perković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2023-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Veliki depresivni poremećaj čest je psihijatrijski poremećaj, no njegova kompleksna patofiziologija i velika heterogenost predstavljaju zapreku u utvrđivanju čimbenika rizika i razvoju boljih terapijskih pristupa. Farmakološka terapija depresije zasniva se velikim dijelom na primjeni antidepresiva. Escitalopram djeluje kao inhibitor ponovne pohrane serotonina, dok vortioksetin pripada multimodalnim lijekovima koji uz inhibiciju SERT-a djeluje i na druge mete, poput 5-HT receptora. Prema neurotrofinskoj teoriji, manjak BDNF-a, koji je bitan za neuralnu plastičnost u pojedinim moždanim regijama, igra ključnu ulogu u nastanku depresije i odražava se također i u uzorcima krvi. U BDNF genu nalazi se više polimorfizama, uključujući Val66Met i C270T polimorfizam, koji se povezuju s promjenama u ekspresiji i procesuiranju BDNF-a, kao i s razvojem različitih psihijatrijskih bolesti, uključujući i depresiju. Cilj ovog rada bio je istražiti povezanost koncentracije BDNF-a u plazmi, te BDNF Val66Met i C270T polimorfizama s razvojem depresije, težinom depresivnih simptoma i učinkom antidepresivnih lijekova. Istraživanje je potvrdilo sniženu koncentraciju BDNF-a u plazmi depresivnih bolesnika. Ispitanici s ponavljanim epizodama depresije imali su težu kliničku sliku od ispitanika sa prvom epizodom depresije, no ona se nije značajno razlikovala nakon 4 tjedna antidepresivne terapije. I vortioksetin i escitalopram, pokazali su se kao učinkoviti antidepresivni lijekovi, ali je samo vortioksetin povisio koncentraciju BDNF-a u plazmi. BDNF Val66Met polimorfizam, za razliku od C270T polimorfizma, utjecao je na bazalnu koncentraciju BDNF-a u plazmi, ali niti jedan nije bio povezan sa razvojem depresije, težinom simptoma i odgovorom na terapiju. Potrebna su daljna istraživanja BDNF-a na većem broju ispitanika, kao i nakon dugotrajne antidepresivne terapije.
Abstract (english)
Major depressive disorder is a common psychiatric disorder; however its complex pathophysiology and large heterogeneity, hinder the determination of risk factors and development of better therapeutic approaches. Pharmacological therapy of depression is largely based on the use of antidepressants. Escitalopram functions as a selective serotonin reuptake inhibitor, while vortioxetine belongs to a new group of multimodal drugs, which, besides SERT inhibition, affects other targets, including 5-HT receptors. According to the neurotrophin theory, lack of BDNF, which is essential for brain neural plasticity, plays a key role in development of depression and is reflected in blood samples. Several BDNF gene polymorphisms, including Val66Met and C270T, are associated with changes in BDNF expression and processing, and development of various psychiatric diseases, including depression. We aimed to investigate the association of BDNF plasma concentrations, BDNF Val66Met and C270T polymorphisms with the development of depression, severity of depressive symptoms and effect of antidepressant drugs. Findings confirmed decreased plasma BDNF concentration in depressed patients. Subjects with repeated depression episodes had more severe clinical picture than patients with a first depression episode, but it was not significantly different after 4 weeks of antidepressant therapy. Both vortioxetine and escitalopram proved to be effective antidepressant drugs, but only vortioxetine increased BDNF plasma concentration. BDNF Val66Met polymorphism, in contrast to C270T polymorphism, affected basal plasma BDNF concentration, but none of them was associated with development of depression, severity of symptoms, and therapy response. Further BDNF studies are needed using larger number of participants, as well as long-term antidepressant therapy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:968411
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-21 12:08:41