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master's thesis
Izazovi u formulaciji multivitaminsko-mineralnih pripravaka
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. urn:nbn:hr:163:414428
Vidović, Lorena
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of food chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Vidović, L. (2023). Izazovi u formulaciji multivitaminsko-mineralnih pripravaka (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:414428

Vidović, Lorena. "Izazovi u formulaciji multivitaminsko-mineralnih pripravaka." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:414428

Vidović, Lorena. "Izazovi u formulaciji multivitaminsko-mineralnih pripravaka." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:414428

Vidović, L. (2023). 'Izazovi u formulaciji multivitaminsko-mineralnih pripravaka', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 13 July 2024, https://urn.nsk.hr/urn:nbn:hr:163:414428

Vidović L. Izazovi u formulaciji multivitaminsko-mineralnih pripravaka [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2023 [cited 2024 July 13] Available at: https://urn.nsk.hr/urn:nbn:hr:163:414428

L. Vidović, "Izazovi u formulaciji multivitaminsko-mineralnih pripravaka", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:163:414428

Metadata
TitleIzazovi u formulaciji multivitaminsko-mineralnih pripravaka
Title (english)Challenges in the formulation of multivitamin-mineral preparations
AuthorLorena Vidović
MentorKristina Radić (mentor)
Committee memberKristina Radić (predsjednik povjerenstva)
Committee memberDubravka Vitali Čepo (član povjerenstva)
Committee memberPetra Turčić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of food chemistry)
Zagreb
Defense date and country2023-08-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Formulacija multikomponentnih pripravaka, poput multivitaminsko-mineralnih pripravaka (MVMP-a), predstavlja iznimno složen proces zbog velikog broja sastojaka s različitim fizikalno-kemijskim svojstvima. Najznačajniji izazovi u formulaciji uključuju topljivost, stabilnost i međusobne interakcije sastojaka. Stabilnost vitamina, posebno vitamina C (askorbinske kiseline), može biti narušena tijekom proizvodnog postupka i skladištenja pripravka. Dodavanje antioksidansa u formulaciju može spriječiti promjenu boje askorbinske kiseline uslijed oksidacije. Primjena odgovarajućih proizvodnih postupaka, poput smanjenja ukupne količine vode u pripravku ili liofilizacije, te keliranje minerala, pridonosi povećanju stabilnosti MVMP-a. Također, dodatak emulgatora i adsorbensa osigurava pravilno uklapanje vitamina topivih u vodi i mastima u MVMP. Kako bi se prikrili neugodni okusi minerala, provode se postupci oblaganja, enkapsulacije i upotreba kelirajućih agensa. Razumijevanje učinka pojedinih sastojaka i osnovnih izazova u formulaciji MVMP-a ključno je za pružanje utemeljenih preporuka, učinkovitu edukaciju, informirane odluke o upotrebi MVMP-a i osiguravanje sigurnosti pacijenata.
Abstract (english)
The formulation of multicomponent preparations, such as multivitamin-mineral preparations (MVMP), is an exceptionally complex process because of the large number of ingredients with different physical and chemical properties. The most significant challenges in formulation include solubility, stability, and interactions between the ingredients. The stability of vitamins, especially vitamin C (ascorbic acid), can be impaired during the production and storage of the preparation. The addition of antioxidants to the formulation can prevent the discoloration of ascorbic acid due to oxidation. The use of appropriate production procedures, such as reducing the total amount of water in the preparation or lyophilization, as well as mineral chelation, contributes to increasing the stability of MVMP. Also, the addition of emulsifiers and adsorbents ensures proper incorporation of water-soluble and fat-soluble vitamins into MVMP. Coating, encapsulation, and the use of chelating agents are used to mask the unpleasant taste of minerals. Understanding the effect of individual ingredients and the main challenges in MVMP formulation is critical for providing evidence-based recommendations, effective education, informed decisions about MVMP use and ensuring patient safety.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:414428
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-21 12:41:06