prikaz prve stranice dokumenta Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova
  Download
PDF 1.37 MB
master's thesis
Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. urn:nbn:hr:163:008285
Turudić, Jelena
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Turudić, J. (2023). Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:008285

Turudić, Jelena. "Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:008285

Turudić, Jelena. "Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2023. https://urn.nsk.hr/urn:nbn:hr:163:008285

Turudić, J. (2023). 'Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:008285

Turudić J. Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2023 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:163:008285

J. Turudić, "Povezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:163:008285

Metadata
TitlePovezanost cirkadijalnog ritma s kroničnim bolestima i djelovanjem lijekova
Title (english)Association between circadial rhythm, cronic diseases and the drug actions
AuthorJelena Turudić
MentorLidija Bach-Rojecky (mentor)
Committee memberLidija Bach-Rojecky (predsjednik povjerenstva)
Committee memberSandra Šupraha-Goreta (član povjerenstva)
Committee memberJasna Jablan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2023-06-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U ovom diplomskom radu opisani su mehanizmi utjecaja cirkadijalnog ritma na farmakokinetske karakteristike lijekova te povezanost abnormalnosti cirkadijalnog ritma s razvojem kroničnih bolesti poput hipertenzije, astme i šećerne bolesti. Cirkadijalni ritam razvijen je evolucijski u većini živih organizama kao odgovor na ponavljajuće dnevne promjene u okolišnim čimbenicima. Središnji regulatorni „sat“ čini suprahijazmatska jezgra u hipotalamusu, dok se periferni „satovi“ nalaze u stanicama perifernih tkiva te međusobno komuniciraju putem živčanih i humoralnih signala. Cirkadijalni ritam pomaže u održavanju homeostaze organizma na način da vremenski usklađuje različite fiziološke procese. Zaslužan je za ritmičnu ekspresiju gena, normalno funkcioniranje imunosnog sustava, ritmičnu kontrolu krvnog tlaka, održavanje razina glukoze u krvi, ali i za brojne druge funkcije. Utvrđeno je postojanje utjecaja cirkadijalne ritmičnosti na farmakokinetske procese apsorpcije, distribucije, metabolizma i eliminacije određenih lijekova. Kronoterapija, odnosno primjena lijeka u optimalno vrijeme unutar 24 sata ima za cilj poboljšanje sigurnosti i učinkovitosti liječenja te postizanje boljih kliničkih ishoda liječenja.
Abstract (english)
In this dissertation, the influence of the circadian rhythm on the pharmacokinetic characteristics of drugs are described, as well as the connection between circadian rhythm abnormalities and the development of chronic diseases such as hypertension, asthma and diabetes.The circadian rhythm has been developed in most living organisms in response to recurring daily changes in environmental factors. The central regulatory "clock" consists of the suprachiasmatic nucleus in the hypothalamus, while the peripheral "clocks" are located in the cells of peripheral tissues and communicate with each other via nerve and humoral signals. The circadian rhythm helps to maintain the homeostasis of the organism by synchronizing various physiological processes. It is responsible for the rhythmic expression of genes, the normal functioning of the immune system, the rhythmic control of blood pressure, the maintenance of blood glucose levels and for numerous other functions. The influence of circadian rhythmicity on the pharmacokinetic processes of absorption, distribution, metabolism and elimination of certain drugs has been established. Chronotherapy (application of the drug at the optimal time within 24 hours) aims to improve the safety and effectiveness of the treatment and achieve better clinical outcomes of the treatment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:008285
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-04-02 11:21:53