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master's thesis
Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:646536
Jagodić, Lucija
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Jagodić, L. (2024). Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:646536

Jagodić, Lucija. "Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:646536

Jagodić, Lucija. "Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:646536

Jagodić, L. (2024). 'Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 28 July 2024, https://urn.nsk.hr/urn:nbn:hr:163:646536

Jagodić L. Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 July 28] Available at: https://urn.nsk.hr/urn:nbn:hr:163:646536

L. Jagodić, "Nove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:646536

Metadata
TitleNove farmakoterapijske mogućnosti liječenja infekcija uzrokovanih ESKAPE patogenima
Title (english)Novel pharmacotherapy possibilities for treatment of infections caused by ESKAPE pathogens
AuthorLucija Jagodić
MentorPetra Turčić (mentor)
Committee memberPetra Turčić (predsjednik povjerenstva)
Committee memberMaja Ortner Hadžiabdić (član povjerenstva)
Committee memberIvana Perković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2024-03-19, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Antibiotici su nam godinama služili kao dragocjeno oružje u borbi s bakterijskim infekcijama i u današnje doba teško je zamisliti život bez njih. Visoka učestalost višestrukorezistentnih sojeva bakterija, s naglaskom na patogene okrunjene akronimom ESKAPE, i otežan razvoj novih antibiotika značajno ograničavaju mogućnosti u terapiji bakterijskih infekcija i često dovode do nepovoljnih kliničkih ishoda. Osim zbog neadekvatne mogućnosti osiguranja zdravlja različitih skupina pacijenata, ove su infekcije i financijski teret za zdravstvo. Problem je prisutan na globalnoj razini i nužno je što brže djelovanje u razvoju lijekova s drukčijim mehanizmima djelovanja. Pojava višestrukorezistentnih sojeva predstavlja veliku opasnost u zdravstvenom sustavu, što se posebice odnosi na pacijente već narušenog zdravlja koji ovakve infekcije najčešće steknu boravkom u ustanovama povezanim sa zdravstvenom skrbi. Kako bismo si osigurali dovoljno vremena za istraživanje novih terapijskih opcija za sprječavanje i liječenje bakterijskih infekcija, moramo se fokusirati na očuvanje učinkovitosti postojećih antibiotika. Iako mnoge alternative antibioticima pokazuju potencijal u rješavanju gorućeg problema antimikrobne rezistencije, u ovom trenutku i dalje nemamo ništa konkretno, stoga nam ne preostaje ništa osim ulagati više napora u bazična i klinička istraživanja
Abstract (english)
For decades antibiotics have served as a valuable weapon in the fight against bacterial infections which is why it is impossible to imagine a world without them. However, increasing incidence of MDR strains, especially pathogens summarised by acronym ESKAPE, along with challenges in development of new antibiotics, all contribute to significant limitations in antimicrobial therapies which often result in unwanted clinical outcomes. Besides inadequate care for various groups of patients, these infections act as a financial burden to healthcare systems. The problem is present across the globe and it is important to act quicker when it comes to development of new drugs with different acting mechanisms. The MDR phenomenon presents a serious threat to healthcare systems, which is particularly important for patients with pre-existing comorbidity who are usually the most prone to these types of pathogens by residing in various health care facilities. Although alternatives to antibiotics demonstrate some potential in resolving antimicrobial resistance, we do not have a conclusive solution which is why it is important to invest more effort into basic and clinical trials.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:646536
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-05-23 14:06:05