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master's thesis
Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:600919
Vlah, Lara
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of food chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Vlah, L. (2024). Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:600919

Vlah, Lara. "Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:600919

Vlah, Lara. "Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:600919

Vlah, L. (2024). 'Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 13 July 2024, https://urn.nsk.hr/urn:nbn:hr:163:600919

Vlah L. Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 July 13] Available at: https://urn.nsk.hr/urn:nbn:hr:163:600919

L. Vlah, "Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:600919

Metadata
TitleSustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima
Title (english)Systematic review of interactions of dietary supplements and drugs used in secondary therapy of myocardial infarction based on evidence
AuthorLara Vlah
MentorKristina Radić (mentor)
Committee memberKristina Radić (predsjednik povjerenstva)
Committee memberDubravka Vitali Čepo (član povjerenstva)
Committee memberAndrea Brajković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of food chemistry)
Zagreb
Defense date and country2024-02-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Infarkt miokarda predstavlja značajno kardiovaskularno oboljenje s visokom prevalencijom širom svijeta. U svrhu prevencije ponovnih kardiovaskularnih komplikacija, pacijentima se prepisuje sekundarna terapija koja obuhvaća širok spektar lijekova, poput β-blokatora, antitrombotika, statina, ACE-inhibitora, uz istovremenu kontrolu faktora rizika. Uz to, sve češće se primjećuje da pacijenti, koji su preživjeli infarkt miokarda, mijenjaju svoje životne navike te koriste dodatke prehrani u nadi poboljšanja općeg zdravstvenog stanja. S obzirom na kompleksnost terapije i sveprisutnu upotrebu dodataka prehrani, postaje izrazito važno prepoznati moguće interakcije između lijekova i dodataka prehrani. Upravo farmaceuti igraju ključnu ulogu u prevenciji, prepoznavanju i upravljanju tim interakcijama kako bi osigurali adekvatnu skrb za pacijente. Stoga ovaj diplomski rad pruža sustavan pregled interakcija između dodataka prehrani i lijekova korištenih u sekundarnoj terapiji infarkta miokarda, temeljen na znanstvenim dokazima. Pritom su objašnjeni raznoliki mehanizmi interakcija, kao što su smanjenje bioraspoloživosti, nefrotoksičnost, hepatoksičnost, te promjene farmakokinetike lijekova. Ova tema ne samo da je relevantna zbog česte pojavnosti infarkta miokarda, već i zbog specifičnih izazova koje donosi u ljekarničkoj praksi. Diplomski rad pridonosi razvoju stručnosti farmaceuta u optimalnom upravljanju terapijom pacijenata nakon infarkta miokarda, čime se direktno utječe na zdravstveno stanje i kvalitetu života pacijenata.
Abstract (english)
Myocardial infarction is a significant cardiovascular disease with a high prevalence worldwide. In order to prevent repeated cardiovascular complications, patients are prescribed secondary therapy that includes a wide range of drugs, such as β-blockers, antithrombotics, statins, ACE-inhibitors, with simultaneous control of risk factors. In addition, it is increasingly noticed that patients, who have survived a myocardial infarction, change their lifestyle and use dietary supplements with hope of improving their general health. Considering the complexity of therapy and the ubiquitous use of dietary supplements, it becomes extremely important to recognize possible interactions between drugs and dietary supplements. Pharmacists play a key role in the prevention, recognition and management of these interactions in order to ensure adequate care for patients. Therefore, this thesis provides a systematic review of the interactions between dietary supplements and drugs used in the secondary therapy of myocardial infarction, based on scientific evidence. Various mechanisms of interactions, such as reduction of bioavailability, nephrotoxicity, hepatotoxicity, and changes in drug pharmacokinetics were explained. This topic is not only relevant because of the high prevalence of myocardial infarction, but also because of the specific challenges it brings in pharmaceutical practice. The diploma thesis contributes to the development of the expertise of pharmacists in the optimal management of therapy for patients after myocardial infarction, which directly affects their health status and quality of life.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:600919
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-12 13:26:30