| Abstract | Prema podatcima Svjetske zdravstvene organizacije i Hrvatskog zavoda za javno zdravstvo, CRC je treći po redu najučestaliji karcinom u svijetu te prvi u Hrvatskoj. Po smrtnosti, nalazi se na drugome mjestu, odmah nakon raka pluća, a bilježi oko 900 000 smrtnih slučajeva u 2020. godini. U posljednjem desetljeću zamijećen je porast broja oboljelih. Uz stariju životnu dob, čimbenici rizika za razvoj bolesti jesu i obiteljska povijest bolesti, upalne bolesti crijeva, pretilost, pušenje, prehrana bogata crvenim mesom, odnosno stil života. Cilj provedenog istraživanja bio je ispitati parametre KKS-a i biomarkere povezane s upalom, MPV/PC-a, PLR-a, NLR-a, LWR-a, LMR-a, NMR-a i LCR-a u pacijenata s CRC-om te onih s adenomom. Istraživanje je obuhvatilo 155 pacijenata podijeljenih u dvije grupe, 81 s CRC-om i 74 s adenomom, s obzirom na nalaz patohistološke analize. Parametri KKS-a određeni su na hematološkom analizatoru Symsex-XN (Sysmex Inc, Kobe, Japan), koncentracija CRP-a izmjerena je na analizatoru Alinity ci-series (Abbot Diagnostics, Abbot Park, IL, USA), a statistička analiza i analiza ROC krivulja napravljena je korištenjem MedCalc® statističkog softwarea verzije 22.014 (MedCalc Software Ltd, Ostend, Belgium). Koncentracija hemoglobina, hematokrit, MCV, MCH i MCHC bili su niži, a RDW viši u skupini pacijenata s CRC-om. Apsolutni broj leukocita, neutrofila i monocita niži je u pacijenata s CRC-om, dok je apsolutni i relativan broj eozinofila kao i relativni broj bazofila u istoj grupi bio viši negoli u skupini pacijenata s adenomom. Broj trombocita bio je značajno viši, a MPV značajno niži u skupini pacijenata s CRC-om. Od svih ispitanih biomarkera povezanih s upalom, jedino su MPV/PC i PLR pokazali statistički značajnu razliku između dviju skupina, uz niže vrijednosti MPV/PC-a i više vrijednosti PLR-a u skupini pacijenata s CRC-om. Unatoč postojanju razlike, analizom ROC krivulja niti jedan ispitani parametar nije pokazao zadovoljavajuću dijagnostičku točnost za razlikovanje dviju skupina. |
| Abstract (english) | According to the World Health Organization’s and the Croatian Institute of Public Health’s data, CRC is the third most common cancer in the world and first in Croatia. In terms of mortality, it is in second place, right after lung cancer, with around 900,000 deaths in 2020. An increase in the number of patients has been observed in the last decade. In addition to older age, risk factors for the development of the disease also include a family history of diseases, inflammatory bowel diseases, obesity, smoking, a diet rich in red meat, or in other words, lifestyle. The aim of the research was to examine parameters of CBC and biomarkers related to inflammation, MPV/PC, PLR, NLR, LWR, LMR, NMR and LCR in CRC patients and those with adenoma. The research included 155 patients divided into two groups, 81 with CRC and 74 with adenoma, based on the pathohistological analysis. CBC parameters were determined on a Symsex-XN hematology analyzer (Sysmex Inc, Kobe, Japan), CRP concentration was measured on an Alinity ci-series analyzer (Abbot Diagnostics, Abbot Park, IL, USA), statistical and the ROC curve analysis was made using MedCalc® statistical software version 22.014 (MedCalc Software Ltd, Ostend, Belgium). Hemoglobin concentration, hematocrit, MCV, MCH and MCHC were lower, and RDW higher in the group of patients with CRC. The absolute number of leukocytes, neutrophils and monocytes was lower in patients with CRC, while the absolute and relative number of eosinophils as well as the relative number of basophils in the same group was higher than in the group of patients with adenoma. Platelet count was significantly higher and MPV significantly lower in the group of patients with CRC. Of all the investigated biomarkers related to the inflammation, only MPV/PC and PLR showed a statistically significant difference between the two groups, with lower values of MPV/PC and higher values of PLR in the group of patients with CRC. Despite the existence of the difference, after ROC curve analysis, none of the examined parameters showed satisfactory diagnostic accuracy for distinguishing the two groups. |
