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master's thesis
Metabolizam lijekova za liječenje kardiovaskularnih bolesti
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:915645
Medak, Anamaria
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Medak, A. (2024). Metabolizam lijekova za liječenje kardiovaskularnih bolesti (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:915645

Medak, Anamaria. "Metabolizam lijekova za liječenje kardiovaskularnih bolesti." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:915645

Medak, Anamaria. "Metabolizam lijekova za liječenje kardiovaskularnih bolesti." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:915645

Medak, A. (2024). 'Metabolizam lijekova za liječenje kardiovaskularnih bolesti', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:915645

Medak A. Metabolizam lijekova za liječenje kardiovaskularnih bolesti [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:915645

A. Medak, "Metabolizam lijekova za liječenje kardiovaskularnih bolesti", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:915645

Metadata
TitleMetabolizam lijekova za liječenje kardiovaskularnih bolesti
Title (english)Metabolism of drugs for the treatment of cardiovascular diseases
AuthorAnamaria Medak
MentorMonika Barbarić (mentor)
Committee memberMonika Barbarić (predsjednik povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
Committee memberAna Karković Marković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2024-06-26, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Kardiovaskularne bolesti su vodeći uzrok mortaliteta, a lijekovi koji se koriste u terapiji pripadaju najkorištenijim lijekovima na svijetu. Imaju ključnu ulogu u kontroli simptoma, liječenju, usporavanju progresije bolesti, kao i smanjenju rizika od ozbiljnih komplikacija. Lijekove možemo podijeliti u nekoliko kategorija prema ciljevima terapije i mehanizmu djelovanja: antihipertenzivi (inhibitori angiotenzin konvertirajućeg enzima (ACEi), blokatori receptora angiotenzina II (ARB), blokatori adrenergičkih receptora, blokatori kalcijevih kanala, antitrombotici (antikoagulansi, inhibitori agregacije trombocita), antiaritmici, hipolipemici i diuretici. Cilj diplomskog rada bio je prikazati metabolizam navedenih skupina lijekova koji se koriste u terapiji kardiovaskularnih bolesti s naglaskom na reakcije biotransformacije, svojstva metabolita i enzime uključene u biotransformaciju. Navedeni su i čimbenici koji mogu utjecati na varijabilnost u odgovoru na terapiju poput genetskih polimorfizama enzima i interakcija lijek-lijek. Rezultati pregleda literature naglašavaju važnost razumijevanja metabolizma lijekova i individualizirani pristup terapiji u skladu s postojećim komorbiditetima i specifičnostima pacijenta.
Abstract (english)
Cardiovascular diseases are the leading cause of mortality, and the medications used in their therapy are among the most widely used drugs in the world. They play a crucial role in controlling symptoms, treating the disease, slowing its progression, and reducing the risk of serious complications. These medications can be categorized into several groups based on therapeutic goals and mechanisms of action: antihypertensives (angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin II receptor blockers (ARBs), adrenergic receptor blockers, calcium channel blockers), antithrombotics (anticoagulants, platelet aggregation inhibitors), antiarrhythmics, hypolipidemics, and diuretics. The aim of this thesis was to present the metabolism of these groups of drugs used in the treatment of cardiovascular diseases, with a focus on biotransformation reactions, properties of metabolites, and enzymes involved in biotransformation. Factors that may influence variability in therapeutic response, such as genetic polymorphisms of enzymes and drug-drug interactions, were also described. The literature review results emphasize the importance of understanding drug metabolism and the individualized approach to therapy in accordance with existing comorbidities and patient-specific characteristics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:915645
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-20 11:58:01