prikaz prve stranice dokumenta Preparation and characterization of Polymersomes for application in cancer therapy
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master's thesis
Preparation and characterization of Polymersomes for application in cancer therapy
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. urn:nbn:hr:163:721930
Dakić, Nikolina
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Dakić, N. (2016). Preparation and characterization of Polymersomes for application in cancer therapy (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:721930

Dakić, Nikolina. "Preparation and characterization of Polymersomes for application in cancer therapy." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:721930

Dakić, Nikolina. "Preparation and characterization of Polymersomes for application in cancer therapy." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:721930

Dakić, N. (2016). 'Preparation and characterization of Polymersomes for application in cancer therapy', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 31 August 2024, https://urn.nsk.hr/urn:nbn:hr:163:721930

Dakić N. Preparation and characterization of Polymersomes for application in cancer therapy [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2016 [cited 2024 August 31] Available at: https://urn.nsk.hr/urn:nbn:hr:163:721930

N. Dakić, "Preparation and characterization of Polymersomes for application in cancer therapy", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:163:721930

Metadata
TitlePreparation and characterization of Polymersomes for application in cancer therapy
AuthorNikolina Dakić
MentorJasmina Lovrić (mentor)
Committee memberJasmina Lovrić (predsjednik povjerenstva)
Committee memberAnita Hafner (član povjerenstva)
Committee memberDubravka Vitali Čepo (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2016-06-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Since the conventional anticancer drugs encounter many obstacles, nanotechnology offers a wide range of new possibilities among which are polymersomes (Ps) as potential drug delivery systems. The aim of this study was to prepare and characterize Ps made out of poly(dimethylsiloxane)-block-poly(2-methyloxazoline) (PDMS-b-PMOXA) diblock copolymer, to test their stability and finally their behaviour towards two different breast cancer cell lines. The results of the study included size and polydispersity index (PDI) of the nanosystems determined by using dynamic light scattering (DLS). Furthermore, imaging of the particles was done using transmission electron microscopy (TEM) while the stability was tested in two different buffers relevant for the study. In vitro experiments, in particular cell viability assay, were done on MDA-MB-231 and MCF-7 breast cancer cell lines.
Abstract (croatian)
Nanotehnologija može značajno pridonijeti razvoju antitumorskih lijekova. Uklapanjem antitumorskih lijekova u odgovarajuće terapijske nanosustave kao što su polimerosomi može se povećati njihova djelotvornost i/ili sigurnost. Cilj je ovog diplomskog rada bio priprema i karakterizacija polimerosoma građenih od poli(dimetilsiloksan)-blok-poli(2-metiloksazolin) (PDMS-b-PMOXA) diblok kopolimera, ispitivanje njihove stabilnosti i biokompatibilnosti. Veličina čestica te indeks polidisperznosti (PDI) određeni su metodom raspršenja laserske svjetlosti, a oblik i morfologija polimerosoma metodom transmisijske elektronske mikroskopije. Stabilnost polimerosoma ispitana jr koristeći dva različita pufera. Od in vitro pokusa provedeo je ispitivanje biokompatibilnosti koristeći MDA-MB231 i MCF-7 stanične linije.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:163:721930
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-10-27 07:38:41