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master's thesis
Povezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:317986
Karuc, Ivana
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medical biochemistry and haematology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Karuc, I. (2024). Povezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02 (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:317986

Karuc, Ivana. "Povezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:317986

Karuc, Ivana. "Povezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:317986

Karuc, I. (2024). 'Povezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 04 October 2024, https://urn.nsk.hr/urn:nbn:hr:163:317986

Karuc I. Povezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02 [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 October 04] Available at: https://urn.nsk.hr/urn:nbn:hr:163:317986

I. Karuc, "Povezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:317986

Metadata
TitlePovezanost primjene cjepiva Pandemrix i incidencije narkolepsije tipa 1 s obzirom na učestalost alelne varijante HLA-DQB1*06:02
Title (english)Association between the use of the Pandemrix vaccine and the incidence of narcolepsy type 1 with regard to the HLA-DQB1*06:02 allele frequency
AuthorIvana Karuc
MentorAnita Somborac Bačura (mentor)
Committee memberAnita Somborac Bačura (predsjednik povjerenstva)
Committee memberSandra Šupraha-Goreta (član povjerenstva)
Committee memberLidija Bach-Rojecky (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Zagreb
Defense date and country2024-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract
Narkolepsija tipa 1 (NT1) je poremećaj spavanja koji nastaje zbog kronične deficijencije oreksina do koje dolazi zbog selektivnog imunoposredovanog uništenja oreksinskih neurona u hipotalamusu. Osim disregulacije ciklusa spavanje - budnost, bolest se prezentira raznim motoričkim, kognitivnim, psihijatrijskim, metaboličkim i autonomnim simptomima, a najspecifičniji simptom je katapleksija. Etiologija je multifaktorijalna, a uključuje genske, epigenske i okolišne čimbenike. Rizični faktori su pozitivnost na HLA-DQB1*06:02 alelnu varijantu, prethodna infekcija virusom influence H1N1 ili Streptococcus-om te primjena cjepiva protiv influence A H1N1/pdm09 s AS03 adjuvansom (Pandemrix). Patofiziologija bolesti još uvijek je tema istraživanja, no do sad utvrđeni genetički, epidemiološki i eksperimentalni podatci podržavaju hipotezu da je NT1 autoimuna bolest posredovana T-limfocitima usmjerena na oreksinske neurone. Razumijevanje imunopatogeneze NT1 važno je iz javnozdravstvene perspektive jer može usmjeriti daljnja istraživanja u smjeru novih terapijskih mogućnosti narkolepsije i drugih autoimunih bolesti te pomoći uspostaviti globalno koordiniranu mrežu ispitivanja sigurnosti cjepiva kao ključnog čimbenika u borbi protiv budućih pandemija.
Abstract (english)
Narcolepsy type 1 (NT1) is a sleep disorder caused by chronic orexin deficiency that occurs due to selective immune-mediated destruction of orexin neurons in the hypothalamus. In addition to dysregulation of the sleep-wake cycle, the disease presents itself with various motor, cognitive, psychiatric, metabolic, and autonomic symptoms, the most specific symptom being cataplexy. The etiology is multifactorial and includes genetic, epigenetic, and environmental factors. Risk factors include HLA-DQB1*06:02-positivity, previous H1N1 influenza virus or Streptococcus infection, and administration of the AS03-adjuvanted influenza A H1N1/pdm09 vaccine (Pandemrix). The pathophysiology of the disease is still an object of ongoing research, but the genetic, epidemiological, and experimental data established so far support the hypothesis that NT1 is a T-lymphocyte-mediated autoimmune disease targeting orexin-producing neurons. Understanding the immunopathogenesis of NT1 is important from the perspective of public health because it can guide further research toward modern therapeutic approaches to narcolepsy and other autoimmune diseases and also help establish a globally coordinated vaccine safety infrastructure as a crucial factor in the fight against future pandemics.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:317986
Study programmeTitle: Medical biochemistry - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar medicinske biokemije i laboratorijske medicine (sveučilišni magistar medicinske biokemije i laboratorijske medicine)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-25 13:13:02