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master's thesis
Voltametrijske metode za analizu beta blokatora
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:462732
Puljko, Lana
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical analysis

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Puljko, L. (2024). Voltametrijske metode za analizu beta blokatora (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:462732

Puljko, Lana. "Voltametrijske metode za analizu beta blokatora." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:462732

Puljko, Lana. "Voltametrijske metode za analizu beta blokatora." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:462732

Puljko, L. (2024). 'Voltametrijske metode za analizu beta blokatora', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:462732

Puljko L. Voltametrijske metode za analizu beta blokatora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:163:462732

L. Puljko, "Voltametrijske metode za analizu beta blokatora", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:462732

Metadata
TitleVoltametrijske metode za analizu beta blokatora
Title (english)Voltammetric methods for the analysis of beta blockers
AuthorLana Puljko
MentorBiljana Nigović (mentor)
Committee memberBiljana Nigović (predsjednik povjerenstva)
Committee memberŽeljan Maleš (član povjerenstva)
Committee memberSandra Jurić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical analysis)
Zagreb
Defense date and country2024-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Beta blokatori su skupina lijekova koji se propisuju kod različitih kardiovaskularnih bolesti, no često se koriste i kao doping sredstva u raznim sportovima pa je iz tog razlogavrlo važno razviti jednostavne, precizne i osjetljive metode za njihovo određivanje. Elektroanalitičke metode imaju značajnu ulogu i često su korištene metode u svrhu određivanja ove vrste lijekova. U ovom radu dan je pregled radova odabranih različitih voltametrijskih metoda i razvijenih elektrokemijskih senzora dobivenih modifikacijom ugljikovih elektroda za određivanje beta blokatora. Pritom su u ispitivanjima najčešće korištene diferencijalna pulsna voltametrija te pravokutnovalna voltametrija, a od elektroda upotrebljavaju se ugljikova staklasta elektroda, elektroda od ugljikove paste, elektroda od grafitne mine te dijamantna elektroda s primjesama bora. Za modifikaciju površina elektroda najčešće se koriste raznovrsni nanomaterijali, koji se nanose zasebno ili u kombinacijama, s ciljem poboljšanja svojstava elektroaktivnih površina i izvedbenih značajki razvijenih elektroanalitičkih metoda za određivanje beta blokatora. Nanocjevčice ugljika često se koriste kao modifikatori površina ugljikovih elektroda, a njihova upotreba omogućuje nižu granicu detekcije odnosno veću osjetljivost zbog povećanja elektroaktivne površine i njihove elektrokatalitičke aktivnosti. Najčešće upotrijebljena elektroda u analizama beta blokatora jest ugljikova staklasta elektroda čija se površina često modificira s ciljem poboljšanja parametra poput osjetljivosti, selektivnosti i reproducibilnosti.
Abstract (english)
Beta blockers are a group of drugs that are prescribed for various cardiovascular diseases, but they are also often used as doping agents in some sports, so for this reason it is very important to develop a simple, precise and sensitive method for their determination. Electroanalytical methods play a significant role and are often used for determining this type of drugs. This paper provides an overview of selected different voltammetric methods and developed electrochemical sensors obtained by modifying carbon electrodes for the determination of beta blockers. Differential pulse voltammetry and square wave voltammetry were mostly used in the tests, and the electrodes used were glassy carbon electrode, carbon paste electrode, pencil graphite electrode and boron-doped diamond electrode. Various nanomaterials are most often used to modify electrode surfaces, which are applied separately or in combinations, with the aim of improving the properties of electroactive surfaces and the performance characteristics of developed electroanalytical methods for determining beta blockers. Carbon nanotubes are often used as surface modifiers of carbon electrodes, their use enables a lower detection limit and greater sensitivity due to the increase of the electroactive surface and their electrocatalytic activity. The most commonly used electrode in beta blocker analyzes is glassy carbon electrode whose surface is often modified in order to improve parameters such as sensitivity, selectivity and reproducibility.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:462732
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-26 11:45:18