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master's thesis
Kratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. urn:nbn:hr:163:129620
Rakić, Maja
University of Zagreb
Faculty of Pharmacy and Biochemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Rakić, M. (2016). Kratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:129620

Rakić, Maja. "Kratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:129620

Rakić, Maja. "Kratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:129620

Rakić, M. (2016). 'Kratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:129620

Rakić M. Kratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2016 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:129620

M. Rakić, "Kratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:163:129620

Metadata
TitleKratka analitička validacija Blyscan testa za mjerenje koncentracije glikozaminoglikana u urinu
Title (english)Analytical validation of the Blyscan test for measuring the concentration of glycosaminoglycans in urine
AuthorMaja Rakić
MentorKsenija Fumić (mentor)
Committee memberKsenija Fumić (predsjednik povjerenstva)
Committee memberOlga Gornik (član povjerenstva)
Committee memberRoberta Petlevski (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
Zagreb
Defense date and country2016-06-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract
Mukopolisaharidoze su podgrupa lizosomskih bolesti nakupljanja. Zbog svoje patofiziološke kompleksnosti, kroničnog tijeka, zahvaćanja više organa i kliničke heterogenosti, predstavljaju izazov suvremenoj kliničkoj i laboratorijskoj dijagnostici. Pravovremeno postavljanje dijagnoze je preduvijet za početak liječenja. Nakon početne kliničke sumnje laboratorijska dijagnostika započinje mjerenjem glikozaminoglikana (GAG) u urinu. Cilj rada je uvođenje Blyscan kompleta reagenasa u rutinski rad laboratorija, čime bi se trebalo standardizirati i ubrzati mjerenje koncentracije GAG-a. Prema zahtjevima kontrole kvalitete i međunarodne norme ISO 15189, prije uvođenja nove metode u rutinski rad laboratorija potrebno je napraviti kratku validaciju. Validacija je ovjera da su specificirani zahtjevi prikladni za utvrđenu uporabu, a kratka analitička validacija obuhvaća mjerenje preciznosti, istinitosti, linearnosti te ispitivanje referentnih raspona. Dobiveni rezultati zadovoljavaju biološke kriterije i uvjete validacije, te je Blyscan komplet reagenasa pogodan za rutinski rad laboratorija.
Abstract (english)
MPS are a subset of lysosomal storage diseases. Because of its pathophysiological complexity, chronic flow, clinical heterogeneity and envelopment of more organs, they present a challenge to modern medicine and laboratory diagnostics. Early diagnosis is a prerequisite for the start of treatment. After initial clinical suspicion laboratory diagnosis begins by measuring glycosaminoglycan (GAG) in urine. The aim is to introduce the Blyscan reagents kit in the routine work of the laboratory, which is supposed to standardize and accelerate the measurement of the concentration of GAG's. According to the requirements of quality control and international standards ISO 15189, before the introduction of the new method it is necessary to validate. The validation is a verification that the specified requirements have been met for the specified use, a short analytical validation includes the measurement of accuracy, precision, linearity test, and reference range. The results meet the biological criteria and requirements of validation, so the Blyscan reagents kit is introduced into the routine work of the laboratory.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:129620
Study programmeTitle: Medical biochemistry
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra medicinske biokemije (magistar/magistra medicinske biokemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-10-27 09:38:16