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master's thesis
Farmakoterapijske mogućnosti u liječenju distonija
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. urn:nbn:hr:163:700520
Klasić, Nikola
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Klasić, N. (2024). Farmakoterapijske mogućnosti u liječenju distonija (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:700520

Klasić, Nikola. "Farmakoterapijske mogućnosti u liječenju distonija." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:700520

Klasić, Nikola. "Farmakoterapijske mogućnosti u liječenju distonija." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2024. https://urn.nsk.hr/urn:nbn:hr:163:700520

Klasić, N. (2024). 'Farmakoterapijske mogućnosti u liječenju distonija', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:700520

Klasić N. Farmakoterapijske mogućnosti u liječenju distonija [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2024 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:700520

N. Klasić, "Farmakoterapijske mogućnosti u liječenju distonija", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:163:700520

Metadata
TitleFarmakoterapijske mogućnosti u liječenju distonija
Title (english)Pharmacotherapy opportunities in the treatment of dystonia
AuthorNikola Klasić
MentorLidija Bach-Rojecky (mentor)
Committee memberLidija Bach-Rojecky (predsjednik povjerenstva)
Committee memberMonika Barbarić (član povjerenstva)
Committee memberŽeljka Vanić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2024-08-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Distonija je poremećaj pokreta uzrokovan trajnim ili povremenim nevoljnim mišićnim kontrakcijama koje dovode do abnormalnih položaja i pokreta tijela. Terapija distonije je uglavnom simptomatska te je nužan multidisciplinaran pristup u liječenju. Terapiji distonije prethodi pravilna dijagnoza i klasifikacija bolesti. Prva linija liječenja je botulinum toksin koji se može kombinirati s preostalom terapijom koju čine oralni lijekovi i kirurški zahvati te fizikalna terapija. Oralni lijekovi koji se koriste su antikolinergici, dopaminergici, benzodiazepini i baklofen. Od kirurških zahvata zlatni standard u liječenju je duboka stimulacija mozga, dok su ostale metode poput selektivne periferne denervacije i ablativnih metoda rijetko u upotrebi. Uz farmakoterapiju znatno poboljšanje je vidljivo uz istovremenu provedbu fizikalne i potporne terapije. Distonija, često praćena i nemotornim simptomima, kao što su bol, anksioznost, nesanica i dr. znatno ograničava svakodnevni život te je liječenje iznimno važno za olakšanje simptoma i mogućnost ponovnog obavljanja svakodnevnih aktivnosti, poput hodanja, pisanja, vožnje automobila, sviranja instrumenta i govora.
Abstract (english)
Dystonia is a movement disorder caused by persistent or intermittent muscle contractions that result in abnormal body positions and movements. Therapy for dystonia is primarily symptomatic, requiring a multidisciplinary approach to treatment. Proper diagnosis and classification of the disease precede dystonia therapy. The first-line treatment is botulinum toxin, which can be combined with other therapies including oral medications, surgical procedures and physical therapy. Oral medications used include anticholinergics, dopaminergics, benzodiazepines, and baclofen. The gold standard in surgical treatment is deep brain stimulation, while other methods such as selective peripheral denervation and ablative techniques are rarely used. Significant improvement is often observed with pharmacotherapy alongside physical and ocupational therapy. Dystonia symptoms significantly limit everyday life, making treatment crucial for alleviating symptoms and enabling individuals to resume activities like walking, writing, driving, playing instruments, and speaking.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:700520
Study programmeTitle: Pharmacy - integrated undergraduate and graduate - university study
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-11 08:20:32