Driven by the need for simple and economical preparation of synthetically useful deuterated terminal alkynes, this work continues the investigation into the isotopic H/D exchange on the terminal alkyne of 1,1-dimethyl-propargyl alcohol (ROH). Previously, successful deuteration using heavy water (D2O) as the sole reactant with ROH was demonstrated. This study extends that research by adding organic solvents to the reaction mixture. In this case, deuterated acetone and deuterated acetonitrile were used. The reason for their addition is that not all compounds with terminal alkyne groups are soluble in water, and the addition of an organic solvent can increase their solubility in a water-organic solvent mixture. Therefore, it is important to examine how the rate of H/D exchange changes with the addition of organic solvents and whether the reaction is inhibited. 1H NMR spectroscopy was used for the investigation. By recording spectra over time, a gradual decrease in the signal of the alkyne group is observed as the 1H proton is substituted by the 2H isotope, whose signal is not visible in the 1H NMR spectrum. Analysis of the results reveals that the addition of the two organic solvents reduces the reaction rate and that the dependence of the reaction's half-life on the solvent's mass fraction is exponential. At relatively low mass fractions of the organic solvent (up to 20%), the reduction in rate is not significant, while at higher mass fractions, the dependence of the H/D exchange rate on the dielectric constant of the organic solvent is easily noticeable. This thesis can serve as a basis for further research into the influence of various other solvents on the reaction outcome.