Objectives: The aim of this research was to assess the appropriateness of low-dose acetylsalicylic acid (ASA) use in a sample of non-hospitalized elderly patients, i.e. to establish therapeutic problems related to low-dose ASA. The specific objectives were: 1. To determine the proportion of patients who had appropriately prescribed ASA in therapy and to analyze the appropriate indications, 2. To determine the proportion of patients who had inappropriately prescribed ASA and the reasons for inappropriate ASA prescribing, 3. To determine the proportion of patients who had an indication for ASA, but was not prescribed. Patients and methods: The research was conducted on a sample of 391 elderly patients as part of the EuroAgeism Horizon 2020 project. Data were collected in community pharmacies using a questionnaire developed for the purposes of this research. Based on the guidelines for the primary and secondary prevention of cardiovascular events of the leading cardiology societies, criteria were drawn up according to which decisions were made on the appropriateness of prescribing and problems in ASA therapy in patients who use it. Results: A total of 391 patients (143 men and 248 women) participated in the study. The average age was 74.33 (SD=10.65) years, and they had an average of six drugs in their therapy. ASK was used by 73 (18.67%) patients. According to the compiled criteria, 41 (56.16%) had an indication for use, and 32 (43.84%) did not have an indication for the appropriate prescription of ASA. 38 (52.05%) were at increased risk of bleeding, of which 22 (57.89%) did not have a proton pump inhibitor (PPI). 23 patients (22.33%) with cardiovascular disease (CVD) were not prescribed ASA (nor other antiplatelet drugs or anticoagulants). Conclusion: The research results point to a significant proportion of patients in whom the prescription and use of ASA is not in accordance with the current guidelines of cardiology societies and the need for more rational use and administration of ASA to elderly patients, since they are at increased risk of side effects related to bleeding, and at the same time, they are the most frequent users of this drug.