Viral skin infections (diseases) are common appearance, particularly among the children. Most frequently reported are: veruccae vulgares, molluscum contagiosum, herpes simplex, herpes zoster. Herpes viruses cause lifelong infection in the host. After primary infection, herpes virus enters the latent form which is activated after various stimuli. Herpes viruses are widely spread all over the world, and the source of infection is human. Target location of antiviral medicines are viral enzymes. Nucleotide analogs are commonly used in treatment. Certain natural products such as vitamins C and E and balm mint may be useful in the treatment of lesions caused by herpes simplex virus. Varicella zoster virus causes chickenpox as a primary infection and herpes zoster, which is the result of reactivation of the varicella zoster virus. Varicella is highly contagious but lighter disease, more common in children. In healthy children usually resolves spontaneously and without complications, while adults have a higher risk of developing complications. Treatment is symptomatic. Herpes zoster causes inflammatory reactions of the rear root and ganglia of the spinal nerves. Post-herpetic neuralgia can last for a longer period of time. Antiviral therapy is effective if taken within three days after the rash appears, but antiviral therapy does not reduce the risk of post-herpetic neuralgia. Molluscum contagiosum virus belongs to the family of Poxviridae. It causes benign infection which is transmitted by contact and expanded by autoinoculation. Molluscum is spread all over the world and is more common in children. Spontaneously is healing by itself, but treatment is carried out to prevent further spread. There are more than hundred different genotypes of human papillomavirus. HPV causes the formation of warts and various tumors of the squamous epithelium and mucosa. Warts usually affect children and adolescents, although they can occur at any age. They disappear spontaneously within two years, depending on the immune status of patients. The infected epithelium is destroyed by chemical and physical means, and ideal treatment should not cause scarring. There is no specific antiviral therapy that destroys HPV.