prikaz prve stranice dokumenta Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM
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master's thesis
Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. urn:nbn:hr:163:901240
Božić, Katarina
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical analysis

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Božić, K. (2016). Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:901240

Božić, Katarina. "Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:901240

Božić, Katarina. "Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:163:901240

Božić, K. (2016). 'Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:901240

Božić K. Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2016 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:901240

K. Božić, "Predviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:163:901240

Metadata
TitlePredviđanje farmakokinetike i toksičnosti statina primjenom programskih paketa PreADMET i pkCSM
Title (english)Prediction of pharmacokinetics and toxicity of statins using software package PreADMET and pkCSM
AuthorKatarina Božić
MentorAna Mornar Turk (mentor)
Committee memberAna Mornar Turk (predsjednik povjerenstva)
Committee memberBiljana Nigović (član povjerenstva)
Committee memberMaja Šegvić Klarić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical analysis)
Zagreb
Defense date and country2016-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U istraživanju potencijalnih lijekova dugo vremena srž istraživanja predstavljala je potragu za novom molekulom s ciljanom farmakološkom aktivnosti. Danas je poznato kako najprikladniji lijek nije nužno onaj s najznačajnijom aktivnosti, već upravo lijek kod kojeg je odnos između učinkovitosti, sigurnosti, farmakokinetike, interakcije s drugim lijekovima te troškova proizvodnje najprikladniji. Stoga se farmakokinetika lijeka ispituje već u najranijim fazama njegova istraživanja. In silico ispitivanje farmakokinetike lijekova od iznimnog je značaja u najranijim fazama istraživanja budući da omogućava predviđanje farmakokinetike potencijalnog, još nesintetiziranog lijeka. Čitav niz on-line kao i komercijalno dostupnih programa omogućava uvid u farmakokinetičko ponašanje potencijalnog lijeka već unutar nekolikom minuta. No, kako bi se dobili pozdani podaci potrebno je redovito evaluirati njihovu primjenu. Cilj ovog rada bio je ispitati farmakokinetička svojstva lijekova iz skupine statina primjenom dva nova programska paketa: PreADMET i pkCSM. Provedenim istraživanjem uočeno je kako se neki od ispitanih parametra značajno razlikuju ovisno o korištenom računalnom programskom paketu. Stoga je moguće zaključiti kako daljnja istraživanja trebaju biti usmjerena na evaluacija ovih programskih paketa u smislu usporedbe eksperimentalno dobivenih podataka s teorijskim vrijednostima.
Abstract (english)
For a long time the core of the research of potential drugs was the search for a new molecule with a target pharmacological activity. Today it is known that the most appropriate drug is not necessarily the one with the most significant activities, then the drug in which the relationship between the efficiency, safety, pharmacokinetics, interactions with other drugs and the cost of producing the most suitable. Therefore, the pharmacokinetics of the drug tests in the earliest stages of research. In silico study of drugs pharmacokintics is of utmost importance in the earliest stages of research as it allows the prediction of pharmacokinetics of potential, still unsynthetized drug. A whole range of on-line as well as commercially available software provides insight into the pharmacokinetic behaviour of potential drug within a few minutes. But in order to get a reliable data it is necessary to regularly evaluate their application. The aim of this study was to investigate the pharmacokinetic properties of drugs from the group of statins using two new software packages: PreADMET and pkCSM. Conducted research it was observed that some of the examined parameters vary significantly depending on the software package. It is possible to conclude that further research should be focused on the evaluation of these software packages in terms of comparing the experimental data with the theoretical values.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:901240
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-12-01 16:42:38